246873-45-0

Basic information

• Product Name: (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER;5-AMINO-2-BOC-AMINO-INDAN;(5-Amino-indan-2-yl)-carbamic acid ter-butyl ester;tert-butyl 5-amino-2,3-dihydro-1H-inden-2-ylcarbamate
• CAS NO: 246873-45-0
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Product Categories: pharmacetical
• Mol File: 246873-45-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(246873-45-0)
• EPA Substance Registry System: (5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER(246873-45-0)

Safety Data

• Hazardous Substances Data: 246873-45-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as an intermediate compound for the synthesis of more complex molecules in the chemical industry. Its functional groups, such as the amino and carbamic acid groups, allow for further reactions and modifications, making it a versatile building block in the creation of new compounds.
Used in Research Applications:
(5-AMINO-INDAN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a research tool in the field of organic chemistry. Its unique structure and functional groups make it an interesting subject for studying reaction mechanisms, exploring new synthetic pathways, and potentially discovering new applications in various fields, such as pharmaceuticals or materials science.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2975-41-9 2,3-dihydro-1H-inden-2-amine 

Downstream Products

• 1355183-46-8 C₂₆H₃₀N₂O₄ 
• 1355183-48-0 C₂₂H₂₈N₂O₃ 
• 913296-96-5 tert-Butyl 5-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-2,3-dihydro-1H-inden-2-ylcarbamate 

Relevant articles and documents

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Compounds of formula (1) wherein R2—C, R3—C, R4—C or R5—C may be replaced by N; and wherein n is 1, 2 or 3; R1 is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R2, R3, R4 and R5 are independently hydrogen, lower alkyl, lower alkoxy, halo, trifluoromethyl or cyano; R6 is (i) or (ii) m is 1, 2 or 3; R7 is hydrogen, lower alkyl (aryl or heteroaryl)-lower alkyl, lower alkoxy, (aryl or heteroaryl)-lower alkoxy, hydroxy, oxo, lower alkylenedioxy or lower alkanoyloxy; W is O, S or NR8; R8 is —CORa, (iii), —COORd, —SO2Re, hydrogen, optionally substituted lower alkyl, aryl, heteroaryl or (aryl or heteroaryl)-lower alkyl; Ra, Rd and Re, are independently optionally substituted lower alkyl, cycloalkyl, adamantyl, aryl, heteroaryl or (aryl or heteroaryl)-lower alkyl; Rb and Rc are independently hydrogen, cycloalkyl, optionally substituted lower alkyl, aryl, heteroaryl or (aryl or heteroaryl) lower alkyl; or Rb and Rc together represent lower alkylene; and pharmaceutically acceptable salts thereof; and enantiomers thereof; which are useful as inhibitors of microsomal triglyceride transfer protein (MTP) and of apolipoprotein B (apoB) secretion.

Amino-benzocycloalkane derivatives

Compounds of the formula I wherein R2—C, R3—C, R4—C or R5—C may be replaced by N; and wherein n is 1, 2 or 3; R1is aryl, cycloalkyl or heterocyclyl; R2, R3, R4and R5are independently hydrogen, optionally substituted alkyl, halo, amino, substituted amino, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aralkoxycarbonyl, (alkyl, aryl or aralkyl)-thio, (alkyl, aryl or aralkyl)-oxy, acyloxy, (alkyl, aryl or aralkyl)-aminocarbonyloxy; or any two of R2, R3, R4and R5at adjacent positions are alkylenedioxy; R6is hydrogen, optionally substituted alkyl, amino, substituted amino, acylamino, wherein Rais hydrogen or optionally substituted alkyl, Rband Rcare independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; or Rband Rctogether represent lower alkylene or lower alkylene interrupted by O, S, or N—(H, alkyl or aralkyl); Rdis optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; and Reis optionally substituted alkyl, aryl, heterocyclyl, cycloalkyl, amino or substituted amino; and pharmaceutically acceptable salts thereof; and enantiomers thereof; which are useful as inhibitors of microsomal triglyceride transfer protein (MTP) and of apolipoprotein B (ApoB) secretion.