24688-27-5Relevant academic research and scientific papers
Electrochemical oxidative synthesis of 2-benzoylquinazolin-4(3: H)-one via C(sp3)-H amination under metal-free conditions
Hu, Yongzhi,Ma, Xinhua,Hou, Huiqing,Sun, Weiming,Tu, Shuqing,Wu, Mei,Lin, Rongkun,Xu, Xiuzhi,Ke, Fang
, p. 6374 - 6379 (2021/10/12)
An electrochemically induced C(sp3)-H amination of 2-aminobenzamides with ketones using TBAI as a catalyst was developed, and provided 2-benzoylquinazolin-4(3H)-ones under metal-free conditions. The reaction proceeded using the relatively low-toxicity methanol as the solvent, employed molecular oxygen as the ideal green oxidant in a simple undivided cell, and exhibited high atom economy. The mechanism of this C(sp3)-H amination strategy was concluded to involve generation of an acetophenone radical, and its easy further oxidation to form 2-oxo-2-phenylacetaldehyde.
