24694-13-1

Basic information

• Product Name: 2-chloro-N-[4-(5-methyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide
• Synonyms: 2-chloro-N-[4-(5-methyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide
• CAS NO: 24694-13-1
• Molecular Weight: 346.818
• Mol File: 24694-13-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-[4-(5-methyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-[4-(5-methyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide(24694-13-1)
• EPA Substance Registry System: 2-chloro-N-[4-(5-methyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide(24694-13-1)

Safety Data

• Hazardous Substances Data: 24694-13-1(Hazardous Substances Data)

Upstream product

• 144-82-1 sulfamethizole 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

Design and synthesis of new sulfonamides–based flt3 inhibitors

Background: Flt3 is an oncogenic kinase involved in different leukemias. It is most prominently associated with acute myeloid leukemia (AML). Flt3-specific inhibitors have shown promising results in interfering with AML. Methods: The crystallographic structures of two inhibitors complexed within Flt3, namely, quizartinib and F6M, were used to guide the synthesis of new sulfonamide-based Flt3 inhibitors. Results: One of the prepared compounds showed low micromolar anti-Flt3 bioactivity, and interestingly, low micromolar bioactivity against the related oncogenic kinase VEGFR2.