247017-89-6Relevant academic research and scientific papers
PRODRUGS IN THE MODULATION OF INTERLEUKIN
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Page/Page column 58-59, (2021/02/12)
There are disclosed prodrugs of the compounds of the formula. The prodrugs are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
Phosphate prodrugs of PD154075
Zhu, Zhijian,Chen, Huai-Gu,Goel, Om P.,Chan, O. Helen,Stilgenbauer, Linda A.,Stewart, Barbra H.
, p. 1121 - 1124 (2007/10/03)
In the preparation of phosphate prodrugs of PD154075, several strategies of linking a phosphate group to the indole moiety were studied. A novel linker, p-hydroxymethylbenzoyloxymethoxycarbonyl, was discovered to provide the phosphate prodrug of PD154075 (compound 9) with significantly increased aqueous solubility, sufficient stability in aqueous solution and good bio-reconversion in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved.
