247017-96-5

Basic information

• Product Name: [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester
• Synonyms: [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester
• CAS NO: 247017-96-5
• Molecular Weight: 648.158
• Mol File: 247017-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester(247017-96-5)
• EPA Substance Registry System: [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester(247017-96-5)

Safety Data

• Hazardous Substances Data: 247017-96-5(Hazardous Substances Data)

Upstream product

• 42908-86-1 2-Chloromethylbenzoyl chloride 
• 158991-23-2 PD 154075 

Downstream Products

• 247017-98-7 [(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester 
• 247017-97-6 [(R)-2-[1-(2-Iodomethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester 

Relevant articles and documents

Phosphate prodrugs of PD154075

In the preparation of phosphate prodrugs of PD154075, several strategies of linking a phosphate group to the indole moiety were studied. A novel linker, p-hydroxymethylbenzoyloxymethoxycarbonyl, was discovered to provide the phosphate prodrug of PD154075 (compound 9) with significantly increased aqueous solubility, sufficient stability in aqueous solution and good bio-reconversion in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved.