[(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

Base Information

• Chemical Name: [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester
• CAS No.: 247017-96-5
• Molecular Formula: C₃₈H₃₄ClN₃O₅
• Molecular Weight: 648.158
• Mol file: 247017-96-5.mol

Synonyms:[(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

Chemical Property of [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

There total 1 articles about [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Chloromethylbenzoyl chloride (42908-86-1) + PD 154075 (158991-23-2) → [(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-96-5)

Guidance literature:

PD 154075; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃;

2-Chloromethylbenzoyl chloride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(00)00183-9

Reference yield: 100.0%

[(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-96-5) → [(R)-2-[1-(2-Iodomethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-97-6)

Guidance literature:

With sodium iodide; In acetone; Heating;

DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

[(R)-2-[1-(2-Chloromethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester (247017-96-5) → {(R)-1-Methyl-1-((S)-1-phenyl-ethylcarbamoyl)-2-[1-(2-phosphonooxymethyl-benzoyl)-1H-indol-3-yl]-ethyl}-carbamic acid benzofuran-2-ylmethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / NaI / acetone / Heating

2: 83 percent / toluene / Heating

3: 1,4-cyclohexadiene / 10 percent Pd/C / ethanol

With cyclohexa-1,4-diene; sodium iodide; palladium on activated charcoal; In ethanol; acetone; toluene; 1: Iodination / 2: Substitution / 3: Hydrogenolysis;

DOI:10.1016/S0960-894X(00)00183-9

upstream raw materials:

2-Chloromethylbenzoyl chloride

PD 154075

Downstream raw materials:

[(R)-2-[1-(2-Iodomethyl-benzoyl)-1H-indol-3-yl]-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester

[(R)-2-{1-[2-(Bis-benzyloxy-phosphoryloxymethyl)-benzoyl]-1H-indol-3-yl}-1-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzofuran-2-ylmethyl ester