24703-00-2

Basic information

• Product Name: 6-hydroxybetamethasone
• Synonyms: 6-hydroxybetamethasone
• CAS NO: 24703-00-2
• Molecular Formula: C₂₂H₂₉FO₆
• Molecular Weight: 408.4604632
• Mol File: 24703-00-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 613.2°C at 760 mmHg
• Flash Point: 324.6°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 1.34E-17mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: -20°C Freezer
• Solubility: Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• PKA: 12.06±0.70(Predicted)
• CAS DataBase Reference: 6-hydroxybetamethasone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-hydroxybetamethasone(24703-00-2)
• EPA Substance Registry System: 6-hydroxybetamethasone(24703-00-2)

Safety Data

• Hazardous Substances Data: 24703-00-2(Hazardous Substances Data)

Usage

Uses

6β-Hydroxy Betamethasone can be used as analyte in analytical study for detecting betamethasone metabolites in human urine using liquid chromatography coupled to tandem mass spectrometry.

InChI:InChI=1/C22H29FO6/c1-11-6-13-14-8-16(26)15-7-12(25)4-5-19(15,2)21(14,23)17(27)9-20(13,3)22(11,29)18(28)10-24/h4-5,7,11,13-14,16-17,24,26-27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16+,17-,19-,20-,21?,22-/m0/s1

Upstream product

• 5593-20-4 betamethasone dipropionate 

Relevant articles and documents

CORRELATION BETWEEN METABOLISM OF BETAMETHASONE 17,21-DIPROPIONATE AND ADRENAL HYPERTROPHY IN RAT FETUSES

The effects of metabolites of betamethasone 17,21-dipropionate (BMDP) on the hypothalamo-pituitary-adrenocortical axis were assessed by measurements of adrenal weights, after studying the metabolism of BMDP in vivo and in vitro in pregnant rats and mice.After BMDP was injected intravenously at a dose of 5mg/kg into rats and mice in late stages of pregnancy, it disappeared rapidly from the plasma and brain in both mothers and fetuses while betamethasone 17-propionate (BMP) was detected as the main metabolite followed by betamethasone (BM).In vitro studies demonstrated that BMDP was metabolized to BMP in maternal and fetal tissues (plasma, liver, brain and placenta) of both species.The subcutaneous administration of BMP to rats in the late stages of pregnancy induced adrenal hypertrophy in fetuses, though the adrenals of the mothers became atrophic.In the case of mice, both maternal and fetal adrenals became atrophic.Administration of BM produced adrenal atrophy in mothers and fetuses of both species.The subcutaneous administration of 6β-hydroxybetamethasone 17-propionate (6β-OH-BMP) to rat fetuses in utero produced adrenal hypertrophy and 6β-hydroxybetamethasone (6β-OH-BM) showed no effect.These data suggest that BMP is transferred across the placental barrier to produce marked adrenal hypertrophy in rat fetuses.