6-Hydroxybetamethasone

Base Information

• Chemical Name: 6-Hydroxybetamethasone
• CAS No.: 24703-00-2
• Molecular Formula: C₂₂H₂₉FO₆
• Molecular Weight: 408.467
• DSSTox Substance ID: DTXSID60179443
• Wikidata: Q83049986
• Mol file: 24703-00-2.mol

Synonyms:6 beta-hydroxybetamethasone;6-BHBM;6-hydroxybetamethasone;6-hydroxybetamethasone, (11beta,16beta)-isomer;6beta-hydroxybetamethasone

Chemical Property of 6-Hydroxybetamethasone

Chemical Property:

• Vapor Pressure: 1.34E-17mmHg at 25°C
• Melting Point: >248°C (dec.)
• Boiling Point: 613.2±55.0 °C(Predicted)
• PKA: 12.06±0.70(Predicted)
• Density: 1.38±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 408.19481680
• Heavy Atom Count: 29
• Complexity: 837

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

6β-HydroxyBetamethasone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)O
• Isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3C[C@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)O
• Uses: 6β-Hydroxy Betamethasone can be used as analyte in analytical study for detecting betamethasone metabolites in human urine using liquid chromatography coupled to tandem mass spectrometry.

Technology Process of 6-Hydroxybetamethasone

There total 1 articles about 6-Hydroxybetamethasone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

betamethasone dipropionate (5593-20-4) → betamethasone (378-44-9) + Betamethasone propionate (5534-13-4) + 6β-hydroxybetamethasone (24703-00-2,24703-12-6,55879-47-5) + 6β-hydroxybetamethasone 17-propionate (78144-00-0,91677-33-7)

Guidance literature:

With phosphate buffer; air; plasma of 20 d pregnant Sprague-Dawley rat; at 37 ℃; for 1h; Product distribution; metabolism with tissues (plasma, liver, brain, placenta) from mothers and fetuses of Sprague-Dawley rats sacrificed on day 20 of pregnancy and mice on day 17 of pregnancy, further in vivo;

DOI:10.1016/S0039-128X(81)90348-2

upstream raw materials:

betamethasone dipropionate

Refernces