1452-16-0

Basic information

• Product Name: 2-Cyanothiazole
• Synonyms: 2-Cyanothiazole;2-Thiazolecarbonitrile;Thiazol-2-carbonitril
• CAS NO: 1452-16-0
• Molecular Formula: C₄H₂N₂S
• Molecular Weight: 110.13708
• Product Categories: cyanide;Clinical hepatitis b&c drug intermediates
• Mol File: 1452-16-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 203℃
• Flash Point: 76℃
• Appearance: /Solid
• Density: 1.33
• Vapor Pressure: 0.291mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C
• PKA: -1.13±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Cyanothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyanothiazole(1452-16-0)
• EPA Substance Registry System: 2-Cyanothiazole(1452-16-0)

Safety Data

• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 1452-16-0(Hazardous Substances Data)

Usage

Uses

2-Cyanothiazole is used as a intermediate for pharmaceutical and chemical research.

InChI:InChI=1/C4H2N2S/c5-3-4-6-1-2-7-4/h1-2H

Upstream product

• 16733-85-0 thiazole-2-carboxamide 
• 13838-77-2 1,3-thiazole-2-carbaldehyde oxime 
• 10200-59-6 Thiazole-2-carbaldehyde 
• 3034-53-5 2-bromo-1,3-thiazole 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 79265-30-8 2-(trimethylsilyl)thiazole 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 60758-41-0 thiazole-2-carbothioamide 
• 90980-72-6 Thiazol-carbonsaeure-(2)-amidhydrazon 
• 24295-03-2 2-Acetylthiazole 
• 1224573-44-7 3,6-bis(thiazol-2-yl)-pyrrolo[3,4-c]pyrrole-1,4-(2H,5H)-dione 
• 16733-85-0 thiazole-2-carboxamide 
• 212558-27-5 1,3-thiazole-2-carboximidamide 
• 1375182-32-3 C₁₅H₁₀FN₅S₂ 
• 89829-62-9 N-hydroxy-1,3-thiazole-2-carboximidamide 
• 89829-62-9 1,3-thiazole-2-amidoxime 
• 13807-25-5 4-ethoxy-2-phenyl-1-thiazol-2-yl-butan-1-one 
• 247037-82-7 1,3-thiazole-2-carboximidamide hydrochloride 
• 1569735-92-7 N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}-1,3-thiazole-2-carboximidamide 
• 438545-36-9 2-(1H-imidazolyl-2-yl)-thiazole 

Relevant articles and documents

Preparation method of medicinal intermediate 2-cyanothiazole

The invention provides a preparation method of medicinal intermediate 2-cyanothiazole. The preparation method comprises the steps that in a reaction container, N-methylimidazole serves as a reaction solvent, CuI serves as a catalyst, K4[Fe(CN)6] and 2-bro

Synthesis of nitriles from aldehydes with trimethylphenylammonium tribromide and ammonium acetate

Various aromatic and heterocyclic aldehydes were easily converted to respective nitriles with the combination of trimethylphenylammonium tribromide and ammonium acetate in good yields at room temperature.

COMPOUNDS HAVING AN ETHR INHIBITING ACTIVITY - USE OF SAID COMPOUNDS AS DRUGS - PHARMACEUTICAL COMPOSITION AND PRODUCT CONTAINING SAID COMPOUNDS

The present invention relates to compounds of Formula (I), wherein R1 is chosen among the following radicals : (II); (III); (IV), (V), (VI) (VII) and n= 1 or 2 and m=1 or 2 with the proviso that m=2 when R1 is (VIII). The present invention also relates to the use thereof as drugs, more particularly in the treatment of mycobacterial infections and more particularly in the treatment of tuberculosis.