247063-06-5Relevant academic research and scientific papers
Cobalt-Catalyzed Remote Hydroboration of Alkenyl Amines
Lei, Yaqin,Huang, Jiaxin,Zhao, Wanxiang
, p. 7797 - 7802 (2021/10/20)
We here present a generally applicable cobalt-catalyzed remote hydroboration of alkenyl amines, providing a practical strategy for the preparation of borylamines and aminoalcohols. This method shows broad substrate scope and good functional group tolerance, tolerating a series of alkenyl amines, including alkyl-alkyl amines, alkyl-aryl amines, aryl-aryl amines, and amides. Of note, this protocol is also compatible with a variety of natural products and drug derivatives. Preliminary mechanistic studies suggest that this transformation involves an iterative chain walking and hydroboration sequence.
New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation
De Vita, Daniela,Pandolfi, Fabiana,Ornano, Luigi,Feroci, Marta,Chiarotto, Isabella,Sileno, Ilaria,Pepi, Federico,Costi, Roberta,Di Santo, Roberto,Scipione, Luigi
, p. 106 - 113 (2016/12/22)
A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE). The most active compounds 4 and 8, showed 85 and 69% of inhibition at 50 μM, respectively
ALBUMIN-BINDING COMPOUNDS
-
Page/Page column 30, (2010/02/15)
The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.
Hydroboration with pyridine borane at room temperature
Clay, Julia M.,Vedejs, Edwin
, p. 5766 - 5767 (2007/10/03)
Treatment of pyridine borane (Py·BH3) with iodine, bromine, or strong acids affords activated Py·BH2X complexes that are capable of hydroborating alkenes at room temperature. Evidence is presented for an unusual hydroboration mechanism involving leaving group displacement. In contrast to THF·BH3, hydroboration with Py·BH2I selectively affords the monoadducts. The crude hydroboration products are converted into synthetically useful potassium alkyltrifluoroborate salts upon treatment with methanolic KHF2. Copyright
