247089-08-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 247089-07-2 1-(1-aminomethyl-cyclohexyl)-2-benzyloxy-ethanol 
• 766-05-2 cyclohexane carbonitrile 
• 247089-06-1 1-(2-Benzyloxy-1-hydroxy-ethyl)-cyclohexanecarbonitrile 
• 60656-87-3 benzyloxyacetoaldehyde 

Downstream Products

• 247089-09-4 methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester 
• 247089-12-9 2-Aza-spiro[3.5]nonane-1,2-dicarboxylic acid 2-tert-butyl ester 
• 247089-10-7 1-Benzyloxymethyl-2-aza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

Herein, we report the synthesis and structure-activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and spiroazetidines as a P2 substituent that replaced the pyrrolidine moiety of 1 and 2 led to the disco

Synthesis and biological evaluation of conformationally restricted gabapentin analogues

A series of conformationally restricted Gabapentin analogues has been synthesised. The pyrrolidine analogue (R)-2-Aza-spiro[4.5]decane-4-carboxylic acid hydrochloride (3a) had an IC50 of 120nM, similar to that of Gabapentin (IC50 = 140nM), at the Gabapentin binding site on the α2δ subunit of a calcium channel. Compound (3a) also reversed carrageenan induced hyperalgesia in rats.