247089-15-2

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 247089-14-1 trifluoro-methanesulfonic acid 2-benzyl-2-aza-spiro[5.5]undec-4-en-5-yl ester 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 247089-13-0 2-benzyl-2-aza-spiro[5.5]undecan-5-one 
• 111-24-0 1,5-dibromo-pentane 

Relevant academic research and scientific papers

Synthesis and biological evaluation of conformationally restricted gabapentin analogues

A series of conformationally restricted Gabapentin analogues has been synthesised. The pyrrolidine analogue (R)-2-Aza-spiro[4.5]decane-4-carboxylic acid hydrochloride (3a) had an IC50 of 120nM, similar to that of Gabapentin (IC50 = 140nM), at the Gabapentin binding site on the α2δ subunit of a calcium channel. Compound (3a) also reversed carrageenan induced hyperalgesia in rats.