247155-44-8Relevant academic research and scientific papers
Reactions of HDDA-Derived Benzynes with Sulfides: Mechanism, Modes, and Three-Component Reactions
Chen, Junhua,Palani, Vignesh,Hoye, Thomas R.
supporting information, p. 4318 - 4321 (2016/05/09)
We report here reactions of alkyl sulfides with benzynes thermally generated by the hexadehydro-Diels-Alder (HDDA) cycloisomerization. The initially produced 1,3-betaine (o-sulfonium/aryl carbanion) undergoes intramolecular proton transfer to generate a more stable S-aryl sulfur ylide. This can react in various manners, including engaging weak acids (HA) in the reaction medium. This can produce transient ion pairs ArSR2+A- that proceed to the products ArSR + RA. When cyclic sulfides are used, A- opens the ring and is incorporated into the product, an outcome that constitutes a versatile, three-component coupling process.
A robust and modular synthesis of ynamides
Mansfield, Steven J.,Campbell, Craig D.,Jones, Michael W.,Anderson, Edward A.
supporting information, p. 3316 - 3319 (2015/03/04)
A flexible, modular ynamide synthesis is reported that uses trichloroethene as an inexpensive two carbon synthon. A wide range of amides and electrophiles can be converted to the corresponding ynamides, importantly including acyclic carbamates, hindered a
Rhodium(I)-catalyzed [2+2+2] cycloadditions with N-functionalized 1- alkynylamides: A conceptually new strategy for the regiospecific synthesis of substituted indolines
Witulski, Bernhard,Stengel, Thomas
, p. 2426 - 2430 (2007/10/03)
The regiospecific introduction of substituents into the 4-position of 2,3-dihydroindoles (indolines), which is significant for the synthesis of various natural products and pharmaceuticals, was achieved by rhodium(I)- catalyzed cyclotrimerizations of 1 wi
