247196-90-3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 82977-93-3 (+)-R-2-benzyloxypropionic acid chloride 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 207680-77-1 (R)-2-hydroxy-N-methoxy-N-methylpropanamide 

Downstream Products

• 247196-88-9 C₁₆H₁₄F₂O₂ 
• 132489-34-0 (R)-2-(benzyloxy)pentan-3-one 

Relevant academic research and scientific papers

Process for the preparation of 2-hydroxyalkyl halophenones

2-Benzyloxyalkyl halophenones of the formula (3): wherein X1and X2are each independently H, Cl or F, provided that at least one of X1and X2is Cl or F; one of R3and R4is H and the other is optionally substituted benzyloxy; and R5is an unsubstituted alkyl, preferably a C1-6alkyl group. The compounds are useful as intermediates for preparing 2-hydroxyalkyl halophenones.

Studies in polypropionate synthesis: High π-face selectivity in Syn and Anti aldol reactions of chiral boron enolates of lactate-derived ketones

Use of (c)Hex2Bcl/Me2NEt in the aldol reactions of the α'-benzoyloxy ketone 7 with aldehydes leads to high stereoselectivity (97-95.5% ds) for the crystalline anti adducts 11. Under similar conditions, the corresponding benzyl ether 6 favours formation of the syn adducts 9.