247222-88-4Relevant academic research and scientific papers
Cascades to substituted indoles
Rainier, Jon D.,Kennedy, Abigail R.
, p. 6213 - 6216 (2007/10/03)
This paper describes the synthesis of dithioindoles from the free-radical cyclizations of arylisonitriles having pendant alkynes. Also described is the synthesis of substituted indoles and spiro-fused indoles from the coupling of dithioindoles with active hydrogen-containing compounds.
An isonitrile-alkyne cascade to di-substituted indoles
Rainier, Jon D.,Kennedy, Abigail R.,Chase, Eric
, p. 6325 - 6327 (2007/10/03)
Intramolecular tin and sulfur mediated free-radical cyclizations between an aryl isonitrile and a pendant TMS-substituted alkyne give 2,3- disubstituted indoles from 5-exo-dig cyclization and nucleophilic trapping of the resulting indolenine intermediate.
