213334-93-1

Upstream product

• 112671-40-6 2-(trimethylsilylethynyl)formanilide 
• 10113-39-0 N-formyl-2-iodoaniline 
• 95-53-4 o-toluidine 
• 1066-54-2 trimethylsilylacetylene 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 247222-88-4 2-phenylsulfanyl-3-[phenylsulfanyl-(trimethyl-silanyl)-methyl]-1H-indole 
• 371754-51-7 N-allyl-N-((2-trimethylsilylethynyl)phenyl)cyanamide 
• 213334-95-3 ((C₂H₅)3P)2Pd(Cl)(C(CH₃)NC₆H₄C₂Si(CH₃)3) 
• 580-22-3 2-aminoquinoline 
• 213335-03-6 ((C₂H₅)3P)2Pd(Cl)(C(Si(CH₃)3)C₈H₄NCCC₆H₅) 
• 213417-32-4 ((C₂H₅)3P)2Pd(Cl)(C(Si(CH₃)3)C₈H₄NCCC₆H₅) 
• 1309925-91-4 C₂₄H₂₃NSe₂Si 
• 213334-97-5 ((C₂H₅)3P)2Pd(Cl)(C(CCC₆H₅)NC₆H₄C₂Si(CH₃)3) 
• 16886-09-2 3-allylindole 
• 24667-94-5 2-(4-methylphenyl)quinoline 
• 91-63-4 2-methylquinoline 

Relevant academic research and scientific papers

Palladium-Catalyzed Domino Synthesis of 2,3-Difunctionalized Indoles via Migratory Insertion of Isocyanides in Batch and Continuous Flow

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, migratory insertion of isocyanide and triple bond activation followed by a nucleophilic attack (OR?) to construct difunctionalized acyl indoles. The process involves

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines

A highly efficient one-pot synthesis of 2-chloro-3-substituted quinolines has been developed by tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes, which are generated in situ by dehydration of the corresponding N-(2-eth

Cascades to substituted indoles

This paper describes the synthesis of dithioindoles from the free-radical cyclizations of arylisonitriles having pendant alkynes. Also described is the synthesis of substituted indoles and spiro-fused indoles from the coupling of dithioindoles with active hydrogen-containing compounds.

New Access to 2,3-disubstituted Quinolines through Cyclization of o-Alkynylisocyanobenzenes

(Matrix Presented) o-Alkynylisocyanobenzenes underwent nucleophile-induced intramolecular cyclization to give 2,3-disubstituted quinoline derivatives in high yields. In addition to the oxygen and nitrogen nucleophiles such as methanol and diethylamine, the nucleophilic carbon of the enolate of malonate induced the cyclization effectively. Reaction of 1,4-di(trimethylsilylethynyl)-2,3-diisocyanobenzene with methanol afforded 2,9-dimethoxy-1,10-phenanthroline in good yield.