24723-77-1

Basic information

• Product Name: Spongosine
• Synonyms: 2-Methoxyadenosine;Spongosine;Adenosine, 2-methoxy-
• CAS NO: 24723-77-1
• Molecular Formula: C11H15 N5 O5
• Molecular Weight: 297.2673
• Mol File: 24723-77-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 193 °C
• Boiling Point: 705°Cat760mmHg
• Flash Point: 380.2°C
• Appearance: /
• Density: 1.98g/cm³
• Vapor Pressure: 7.3E-21mmHg at 25°C
• Refractive Index: 1.829
• PKA: 13.07±0.70(Predicted)
• CAS DataBase Reference: Spongosine(CAS DataBase Reference)
• NIST Chemistry Reference: Spongosine(24723-77-1)
• EPA Substance Registry System: Spongosine(24723-77-1)

Safety Data

• Hazardous Substances Data: 24723-77-1(Hazardous Substances Data)

Usage

General Description

Spongosine is a bioactive alkaloid chemical compound which was originally isolated from marine sponges of the genus Spongosorites. It exhibits a unique reconstructed pyrrolizidine skeleton that is different from other natural pyrrolizidines and has been noted for its potential antiviral and cytotoxic activities in scientific research studies. Therefore, it is a compound of interest for researchers in the field of drug discovery and medicinal chemistry.

InChI:InChI=1/C11H15N5O5/c1-20-11-14-8(12)5-9(15-11)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)

Upstream product

• 266360-70-7 2-nitroadenosine pentaacetate 
• 67-56-1 methanol 
• 266360-74-1 6-amino-2-nitro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-purine 
• 869477-34-9 2’,3’,5’-O-tri(t-butyldimethylsilyl)-O⁶-methylguanosine 
• 1351797-24-4 2,6-dimethoxy-9-(2,3-bis-O-tert-butyldimetylsilyl-β-D-ribofuranosyl)-9H-purine 
• 35109-91-2 6-chloro-2-methoxy-9-(β-D-ribofuranosyl)-9H-purine 
• 141320-73-2 9-[(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-chloro-9H-purin-2-ylamine 
• 859211-32-8 9-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine 
• 854158-99-9 2-nitro-pentabenzoyl adenosine 
• 88508-72-9 2,6-dimethoxy-9-(β-D-ribofuranosyl)-9H-purine 
• 1839-18-5 6-Amino-2-chlorpurin 
• 15465-92-6 2-chloro-6-methoxy-purine riboside 
• 56720-43-5 2-chloro-2',3'-O-(ethoxymethylidene) adenosine 
• 33436-90-7 2-Ethylthioadenine 

Downstream Products

• 756818-82-3 C₁₇H₁₈N₆O₅ 

Relevant articles and documents

A new method for synthesis of 2-alkoxyadenosine analogs

O6-Methylguanosine and 2-amino-6-chloropurine riboside derivative were treated with isoamylnitrite in the presence of an appropriate alcohol to give the corresponding 2-alkoxy-6-methoxy (or chloro) purine riboside derivatives.

-

-

IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES

Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R = C1-6 alkoxy (straight or branched), a phenoxy group (unsubstitute

Anti-HCV nucleoside derivatives

The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.