247236-09-5

Usage

Uses

Used in Pharmaceutical Industry:
3-((1-(N,N-dimethylaminosulfonyl)-1H-1,2,4-triazol-3-yl)disulfanyl)-N,N-dimethyl-1H-1,2,4-triazole-1-sulfonamide is used as a potential active pharmaceutical ingredient for its possible antifungal or antimicrobial properties due to its unique structural features that may allow it to interact with biological targets effectively.
Used in Medicinal Chemistry Research:
3-((1-(N,N-dimethylaminosulfonyl)-1H-1,2,4-triazol-3-yl)disulfanyl)-N,N-dimethyl-1H-1,2,4-triazole-1-sulfonamide serves as a subject of investigation in medicinal chemistry, where its structural elements, including the triazole ring and sulfonamide group, are explored for their potential to bind with and modulate the activity of various biological targets, thereby contributing to the development of new therapeutic agents.

Upstream product

• 3179-31-5 1H-[1,2,4]triazole-3-thiol 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 14804-01-4 3-(1H-1,2,4-triazol-3-yldisulfanyl)-1H-1,2,4-triazole 

Downstream Products

• 171967-86-5 1-(N,N-dimethylaminosulfonyl)-1H-1,2,4-triazole-3-sulfonyl chloride 

Relevant academic research and scientific papers

Novel triazole compound and application thereof in agriculture

The invention provides a novel triazole compound and application thereof in agriculture. Specifically, the invention relates to a triazole compound shown as a formula (IV) and a preparation method thereof. In the formula (IV), R and R are hydrogen, C1-6 alkyl and the like, X is -CH2-, -CH(CH3)- and the like, and R, R, R, R and R are hydrogen, fluorine, chlorine, bromine, iodine, hydroxyl, cyano, nitro, amino, C1-6 alkyl and the like; the compound, a composition containing the compound and/or a preparation containing the compound have/has good bactericidal activity and can be used as a bactericide in agriculture.

Cyclopentyl substituted disulfonamide compound and application thereof in agriculture

The invention belongs to the field of pesticides, and particularly relates to a cyclopentyl substituted disulfonamide compound and application thereof in agriculture. The compound is shown as a general formula (I). In the formula (I), R and R are hydrogen, C1-6 alkyl and the like, R and R are hydrogen, fluorine, chlorine, bromine or methyl, X is -CH2- and the like, and R, R, R, R and R are hydrogen, fluorine, chlorine, bromine, iodine, hydroxyl, cyano, nitro, amino, C1-6 alkyl and the like; the compound, a composition containing the compound and/or a preparation containing the compound have/has good bactericidal activity and can be used as a bactericide in agriculture.

Triazole sulfonamides derivatives and their use in agriculture

The invention provides a novel triazole sulfonamide derivative and application thereof in agriculture. , The invention relates to a triazole sulfonamides derivative as shown in a formula (I) and a preparation method thereof. I In formula (R)1 And R2 Are each independently hydrogen. C1 -6 Alkyl and the like, R3 Document C3 -8 Cycloalkyl, R4 -SO2 - NRa Rb , SO2 - C1 -6 Alkyl group, SO2 - C3 -8 Cycloalkyl, SO2 - C1 -3 Alkylene - C3 -8 Cycloalkyl, SO2 - Rc , C1 -3 Alkylene - C (＝ O) O-C1 -6 Alkyl or - C1 -3 Alkylene - C (＝ O) - NRd Re , Ra , Rb , Rc , Rd And Re Having the meaning of the invention. The compound, the composition containing the compound and/or the preparation provided by the invention has good bactericidal activity and can be used as a bactericide in agriculture.

Design, Synthesis, and Structure-Activity Relationship of Economical Triazole Sulfonamide Aryl Derivatives with High Fungicidal Activity

Plant fungal diseases have caused great decreases in crop quality and yield. As one of the considerable agricultural diseases, cucumber downy mildew (CDM) caused by pseudoperonospora cubensis seriously influences the production of cucumber. Amisulbrom is a commercial agricultural fungicide developed by Nissan Chemical, Ltd., for the control of oomycetes diseases that is highly effective against CDM. However, the synthesis of amisulbrom has a high cost because of the introduction of the bromoindole ring. In addition, the continuous use of amisulbrom might increase the risk of resistance development. Hence, there is an imperative to develop active fungicides with new scaffolds but low cost against CDM. In this study, a series of 1,2,4-triazole-1,3-disulfonamide derivatives were designed, synthesized, and screened. Compound 1j showed a comparable fungicidal activity with amisulbrom, but it was low cost and ecofriendly. It has the potential to be developed as a new fungicide candidate against CDM. Further investigations of structure-activity relationship exhibited the structural requirements of 1,2,4-triazole-1,3-disulfonamide and appropriate modification in N-alkyl benzylamine groups with high fungicidal activity. This research will provide powerful guidance for the design of highly active lead compounds with a novel skeleton and low cost.

Triazole compound and application thereof in agriculture (by machine translation)

More specifically, the present invention relates to a; method for, preparing a triazole compound (I) represented by formula (I) or a salt (I) thereof, a salt thereof, and a method, for producing a, triazole compound, a salt thereof, and a method for controlling a, disease by using these compounds, and or compositions in the form of a fungicide and a; fungicide ,R composition thereof. 1 , R2 , Y, n, X, R3 , R4 The, m invention has Het .the meanings as described in the present invention. (by machine translation)

TRIAZOLE COMPOUND AND USE THEREOF IN AGRICULTURE

A novel triazole compound of the formula (IV) is provided, it can be used in agriculture, wherein R1 is cyclopropyl and the like; X is -CH2-and the like; each of R4 and R6 is independently hydrogen, fluorine, chlorine, CH3-, etc.; each of R3 and R7 is hydrogen, fluorine, chlorine, idoine, CH3-, -OCF3, etc.; R5 is hydrogen, fluorine, chlorine, bromine, idoine, -CF3, -OCH2CN, -OCH2CH=CH2, etc.

Triazole compound and application thereof in agriculture (by machine translation)

The present invention provides a triazole compound; in particular, nitrogen oxide of a triazole compound represented by Formula (I) or a preparation method (I) of a triazole compound represented by Formula, and a method, of controlling diseases using these compounds or compositions in the form, of a fungicide and application, of the triazole compound and a fungicide composition thereof as fungicides . and ,R. 1 , R2 , X, n, R3 And R4 Having meanings. according to the present invention (by machine translation)

Discovery of a new fungicide by screening triazole sulfonylhydrazone derivatives and its downy mildew inhibition in cucumber

Downy mildew is a very important detrimental disease that lead reduced to fruits and vegetables. Due to the continuous growth of drug resistance, finding novel fungicides with dissimilar modes of function from present fungicides for controlling downy mildew are imminent. This work is an extension of our preceding research on the original triazole sulfonamide derivatives lead compound. Triazole sulfonamide as a remarkable nitrogen-containing heterocyclic compound opposed cucumber downy mildew (CDM) develops a quite vital part in the sphere of the study of new farm chemicals. The existing report designs a certain amount of 1,2,4-triazole-1,3-disulfonamide derivatives. Hydrazones have obtained extensive attention in the field of pharmaceutical due to its unique chemical structure and remarkable activity (insecticidal, antibacterial, antifungal and herbicidal). By means of coupling numerous hydrazone with triazole sulfonyl chloride groups, 24 novel derivatives were synthesized. Spectrum analysis of LC-MS, 1H NMR and 13C NMR were used for characterizing these new compounds. Compared with commercial Cyazofamid using bioassays, most of these compounds displayed preferable fungicidal activities. Moreover, compounds 8q illustrated the greatest CDM resistance (EC50 = 7.776 mg/L). Field efficacy trials revealed that compound 8q fungicidal activity was higher than the purchased agrochemical Cyazofamid and Amisulbrom. Thus, the research declared that 8q displayed a great potential for the application of fungicide against CDM.

Design, Synthesis, and Biological Activity of Novel Triazole Sulfonamide Derivatives Containing a Benzylamine Moiety

The triazole sulfonamide played a very important role in the field of research of new agrochemical compounds as a novel heterocyclic compound with lack of reported resistance. For the research on the innovative triazole sulfonamide fungicide effective against cucumber downy mildew (CDM), the present article designed an array of 1,2,4-triazole-1,3-disulfonamide derivatives. The derivatives were synthesized via coupling multiple benzylamine with triazole sulfonamide groups. 1H-NMR, 13C-NMR, and LC–MS spectrometry were used to characterize these synthesized compounds. Most of these derivatives exhibited better fungicidal activities than that of the commercial cyanosole using bioassays. In particular, compounds 6g and 6h showed the best fungicidal activity against CDM (EC50?=?6.91 and 10.62?mg/L). Comparative experiments demonstrated that the fungicidal activity of 6g and 6h was better than the commercial pesticides amisulbrom and cyanosole. According to the study, the compound 6g had a giant application potential on fungicide against CDM.

Triazole compounds and their use in agriculture (by machine translation)

The present invention provides a triazole compound and its application in agriculture; in particular, the invention provides compounds of formula (A) indicated by the compound and its preparation method; the composition containing these compounds and preparation and their use as fungicides; wherein R1 , R2 , R3 , W, R4 , R5 , R6 , R7 , R8 , R9 , Ra , Rb And in the event of x has the meanings given by the invention. (by machine translation)