247244-38-8

Upstream product

• 247244-37-7 (4S)-(+)-(4-benzyl-2-oxo-oxazolidine-3-yl)-acetic acid ethyl ester 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 

Downstream Products

• 247244-40-2 (S)-2-(4-benzyl-2-oxo-1,3-oxazolidin-3-yl)acetyl chloride 
• 913076-49-0 (S)-4-benzyl-3-(3-diazo-2-oxopropyl)-1,3-oxazolidin-2-one 
• 913076-55-8 (S)-4-benzyl-3-(3-bromo-2-oxopropyl)-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

MONOCYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS

The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Diastereoselective [4+3] cycloadditions of enantiopure nitrogen-stabilized oxyallyl cations

Diastereoselective trapping of chiral enantiopure oxyallyl cations by common dienes is reported. Excellent diastereoselectivities were obtained and depending on which auxiliary was used cycloadditions proceeded through a chelated or non-chelated pathway.

α-Functionalised ketones as promoters of alkene epoxidation by oxone

Acceleration of Oxone epoxidation of alkenes by several α- functionalised ketones, including α-amido ketones, is investigated. In general, competing decomposition by Baeyer-Villiger reaction prevents use of the ketones as efficient epoxidation promoters.