24737-91-5

Upstream product

• 108-32-7 1,2-propylene cyclic carbonate 
• 32316-92-0 naphthalene-2-boronic acid 
• 14823-09-7 6-iodopyridazin-3(2H)-one 
• 93-08-3 methyl 2-naphthyl ketone 
• 1316302-34-7 C₂₃H₁₈O₄ 
• 25370-42-7 Ethyl 4-(2-naphthyl)-4-oxobutanoate 
• 24734-44-9 6-naphthalen-2-yl-4,5-dihydro-2H-pyridazin-3-one 

Downstream Products

• 867130-43-6 3-chloro-6-[2]naphthyl-pyridazine 
• 922881-78-5 C₂₁H₁₅N₃O₃ 
• 1443124-88-6 N⁴,N⁴-diethyl-N¹-(3-((3-(naphthalen-2-yl)-6-oxopyridazin-1(6H)-yl)methyl)phenyl)piperidine-1,4-dicarboxamide 

Relevant academic research and scientific papers

Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Unexpected C-C bond cleavage: A route to 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from 1,3-dicarbonyl compounds and methyl ketones

An unexpected C-C bond cleavage has been revealed in the absence of metal. This observation has been exploited to develop an efficient approach toward 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from simple and commercially available 1,3-dicarbonyl compounds and methyl ketones.