24740-39-4Relevant academic research and scientific papers
Enantio- and Diastereoselective Synthesis of Functionalized Carbocycles by Cu-Catalyzed Borylative Cyclization of Alkynes with Ketones
Zanghi, Joseph M.,Liu, Shuang,Meek, Simon J.
, p. 5172 - 5177 (2019)
A single-pot Cu-catalyzed enantio- and diastereoselective tandem hydroboration/borylative cyclization of alkynes with ketones for the synthesis of carbocycles is reported. The reaction proceeds via desymmetrization and generates four contiguous stereocent
Ni-catalyzed reductive antiarylative cyclization of alkynones
Zhou, Zhijun,Liu, Wenfeng,Kong, Wangqing
supporting information, p. 6982 - 6987 (2020/09/15)
A new catalyst system for the antiarylative cyclization of alkynones and aryl halides through a reductive cross-coupling strategy is developed. The transformation proceeds smoothly in the absence of organometallic reagents and features high functional group tolerance. This method provides an effective platform to access a wide variety of synthetically useful endocyclic tetrasubstituted allylic alcohols in a stereoselective manner.
Organocatalytic Reductive Propargylation: Scope and Applications
Pasha, Mohammed Anif,Krishna, A. Vamshi,Ashok, Etikala,Ramachary, Dhevalapally B.
, p. 15399 - 15416 (2019/12/04)
An amino acid-catalyzed three-component reductive coupling protocol has been developed for the selective high-yielding synthesis of nearly fifty examples of propargylated cyclic/acyclic systems from the various propargyl aldehydes, cyclic/acyclic CH acids, and Hantzsch ester under ambient conditions. It is an economical, efficient, catalytic, metal-free protocol for the quick gram-scale synthesis of propargylated cyclic/acyclic compounds, and many of these coupling compounds were purified by a simple precipitation-filtration technique instead of column chromatography. Functionally rich propargylated cyclic-1,3-diketones were specifically transformed into dihydropyrans found in natural products and drugs through an annulative etherification reaction by using Lewis-acid (AgOTf) catalysis. Further, we developed the C-methylation reactions on propargylated cyclic-1,3-diketones, which are prolific synthons in natural products and medicinal chemistry.
