24740-61-2Relevant academic research and scientific papers
Ruthenium-Catalyzed Alkylation of Cyclopropanols with Sulfoxonium Ylides via C-C Bond Cleavage: Formation of Diverse 1,5-Diketones
Huang, Xin,Li, Jianglian,He, Hua,Yan, Kaichuan,Lai, Ruizhi,Luo, Yi,Guan, Mei,Wu, Yong
, p. 779 - 787 (2021/10/29)
A novel ruthenium-catalyzed alkylation of cyclopropanols with sulfoxonium ylides has been developed that affords diverse 1,5-diketones with good efficiency and broad substrate scope. To illustrate the synthetic applications of the obtained 1,5-diketones, aldol and cyclization reactions have been investigated. Preliminary mechanistic studies suggest that this process involves a sequential C C activation and carbene migratory insertion.
Ruthenium-catalyzed room-temperature coupling of α-keto sulfoxonium ylides and cyclopropanols for δ-diketone synthesis
Fan, Shuaixin,Fang, Lili,Li, Tielei,Wu, Weiping,Zhu, Jin
supporting information, p. 7386 - 7389 (2021/08/03)
Previous transition metal-catalyzed synthesis processes of δ-diketones are plagued by the high cost of the rhodium catalyst and harsh reaction conditions. Herein a low-cost, room temperature ruthenium catalytic method is developed based on the coupling of α-keto sulfoxonium ylides with cyclopropanols. The mild protocol features a broad substrate scope (47 examples) and a high product yield (up to 99%). Mechanistic studies argue against a radical pathway and support a cyclopropanol ring opening, sulfoxonium ylide-derived carbenoid formation, migratory insertion C-C bond formation pathway.
Ruthenium-catalyzed alkylation reaction of cyclopropanol and sulfur ylide for synthesis of 1, 5-diketone compounds
-
Paragraph 0022; 0023, (2020/12/15)
The invention relates to a ruthenium-catalyzed alkylation reaction of cyclopropanol and sulfur ylide, and a series of 1, 5-diketone compounds can be synthesized by the method. According to the method,cyclopropanol is catalyzed by ruthenium to generate beta-carbon elimination ring opening, and safe, stable and easy-to-prepare sulfur ylide is used as a carbene precursor, so that the method has goodapplicability in the field of construction of 1, 5-diketone.
