24743-60-0

Upstream product

• 120-46-7 1,3-diphenylpropanedione 
• 4830-74-4 (4-chlorophenyl)azo 4-methylphenyl sulfone 
• 2028-74-2 p-chlorobenzenediazonium chloride 

Downstream Products

• 139038-73-6 N-(4-Chloro-phenyl)-N'-(5,7-diphenyl-2,3-dihydro-[1,4]diazepin-6-ylidene)-hydrazine 
• 59255-05-9 N'-(4-chloro-phenyl)-2-oxo-2-phenyl-acetohydrazonoyl bromide 
• 136774-15-7 6-Benzoyl-2-(4-chloro-phenyl)-5-phenyl-2H-[1,2,4]triazin-3-one 
• 144881-65-2 5-(4-Chloro-phenylazo)-2-ethylsulfanyl-4,6-diphenyl-nicotinonitrile 
• 444102-98-1 Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[5-(4-chloro-phenylazo)-3-cyano-4,6-diphenyl-pyridin-2-ylsulfanyl]-tetrahydro-pyran-3-yl ester 
• 444102-93-6 Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[5-(4-chloro-phenylazo)-3-cyano-4,6-diphenyl-pyridin-2-ylsulfanyl]-tetrahydro-pyran-3-yl ester 
• 37154-44-2 1,1-dioxo-3,5-diphenyl-1H-1λ⁶-[1,2,6]thiadiazin-4-one (4-chloro-phenyl)-hydrazone 
• 144881-55-0 5-(4-Chloro-phenylazo)-4,6-diphenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Pyridine-Catalysed Desulfonylative Addition of β-Diketones to Arylazosulfones via Diaziridine Rearrangement

A pyridine-catalysed desulfonylative addition of β-diketones to arylazosulfones was developed to obtain diazenyl β-dicarbonyl compounds. The aryldiazenyl group was observed in the desired product from arylazosulfones, and this diazenylation reaction was achieved via a possible rearrangement process based on diaziridine ring cleavage. The scope of the protocol was investigated and a plausible mechanism was given. (Figure presented.).

S1P3 RECEPTOR ANTAGONIST

The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P3 receptors and a medicine containing thereof as an active ingredient. The present invention provides an arylamidrazone derivative represented by' the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a C2-C8 alkyl group which maybe substituted, a phenyl group which maybe substituted, an aromatic heterocyclic group which may be substituted, a C2-C8 alkoxy group which may be substituted, or -NR4R5 (wherein R4 and R5, which are identical or different, each represent a hydrogen atom or a lower alkyl group which may be substituted, or R4 and R5 may be joined with the adjacent nitrogen atom to form a nitrogen-containing heterocyclic ring which may be substituted); R2 and R3, which are identical or different, each represent a hydrogen atom, a halogen atom, a halo-lower alkyl group, a lower alkyl group, a lower alkynyl group, a lower alkoxy group, a cyano group, a lower alkanoyl group or a lower alkylsulfonyl group; A represents a benzene ring or a heterocyclic ring; D represents a single bond or methylene; m represents an integer from 1 to 3, and n represents an integer from 1 to 5 (with the proviso that the case where R1 is an ethoxy group, R2 is a 2,4-dichloro group, R3 is a hydrogen atom, A is a benzene ring, and D is methylene; and the case where R1 is an ethoxy group, R2 is a 2,4-dichloro group, R3 is a hydrogen atom, a 2-methyl group, a 4-methyl group, a 4-methoxy group or a 4-ethoxy group, A is a benzene ring, and D is a single bond, are excluded).

SYNTHESIS OF PYRIDINE-2(1H)-THIONE AND THIENOPYRIDINE DERIVATIVES

A synthesis of pyridine-2(1H)-thiones and thienopyridines utilizing cyanothioacetamide and 2-arylhydrazono-1,3-diphenylpropane-1,3-diones as starting components is described.

Laser Flash Photolysis of Aromatic Azo-hydrazone Systems

Laser flash photolysis using 347 nm excitation and pulse radiolysis have been used to study the transient species produced from solutions of a series of eight hydrazone compounds synthesised from substituted (R1, R2) 1,3-diones coupled to substituted (Ar) aromatic amines.Three classes of transient behaviour were found in hexane solution.Compound (8) gave a very short-lived transient (t1/2 ca. 45 ns, λmax. 510 nm) which was identified as a triplet species.The other three compounds from unsymmetrical dione derivatives gave short-lived transients (t1/2 ca. 50-100 μs) in the spectral region 440-460 nm and long-lived transients (t1/2 ca. 0.5-2.0 s) occuring at ca. 425 nm, whereas the four symmetrical derivatives (R1=R2) gave only the short-lived transients in the region 450-470 nm.The lifetimes of the longer-lived transients were shown to be dependent on solvent polarity and added acid.It is proposed that the longer-lived transients are associated with isomerism about the C=N bond, induced by photoexcitation into the singlet excited state.Rate constants for quenching of various triplet species by three of the hydrazones were determined and shown to correlate with the triplet energy of the compounds being quenched.Assuming quenching occurred by electronic energy transfer the triplet energies of the hydrazones were estimated to lie in the range 150-190 kJ mol-1.The photochemical breakdown products arising from extensive u. v. irradiation have been examined by chromatographic and spectroscopic techniques.It was shown that the compounds are relatively stable to irradiation above 330 nm.