59255-05-9

Upstream product

• 24743-60-0 2-(2-(4-chlorophenyl)hydrazono)-1,3-diphenylpropane-1,3-dione 

Downstream Products

• 125041-28-3 5-Amino-3-benzoyl-1-(4-chloro-phenyl)-1H-pyrazole-4-carbonitrile 
• 934368-82-8 2-(4-chlorophenylhydrazono)-2-(3-fluorophenylamino)acetophenone 
• 1161946-72-0 ethyl 2-(2-(4-chlorophenyl)azo)-5,6-dihydro-8,9-dimethoxy-3-phenylpyrrolo[2,1-a]isoquinoline-1-carboxylate 
• 1177417-38-7 3-benzoyl-1-(4-chlorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[2,3-d]-1,2,4-triazolo[4,5-a]pyrimidin-5-one 
• 1332697-77-4 3-(4-chlorophenyldiazenyl)-4,7,7-triphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 
• 1403935-91-0 3-[1-(2-(5-((4-chlorophenyl)diazenyl)-4-phenylthiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-one 
• 1412890-50-6 3-[4-chlorophenylazo]-6-methyl-2,8,9-triphenyl-8H-imidazo[1,2-b]pyrazolo[4,3-d]pyridazine 
• 1448522-01-7 5-[(4-chlorophenyl)diazenyl]-2-[2-(1-(naphthalen-2-yl)ethylidene)hydrazinyl]-4-phenylthiazole 
• 1403660-02-5 2-[(3-benzoyl-1-(4-chlorophenyl)-1H-4-pyrazolyl)carbonyl]-3-methyl-5,6-diphenylimidazo[2,1-b]thiazole 
• 59775-66-5 [4-(4-chloro-phenyl)-5-nitrosoimino-4,5-dihydro-[1,3,4]thiadiazol-2-yl]-phenyl-methanone 
• 59775-70-1 5-benzoyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-2-one 
• 55716-46-6 5-benzoyl-2-imino-3-(p-chlorophenyl)-2,3-dihydro-1,3,4-thiadiazole 

Relevant academic research and scientific papers

S1P3 RECEPTOR ANTAGONIST

The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P3 receptors and a medicine containing thereof as an active ingredient. The present invention provides an arylamidrazone derivative represented by' the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a C2-C8 alkyl group which maybe substituted, a phenyl group which maybe substituted, an aromatic heterocyclic group which may be substituted, a C2-C8 alkoxy group which may be substituted, or -NR4R5 (wherein R4 and R5, which are identical or different, each represent a hydrogen atom or a lower alkyl group which may be substituted, or R4 and R5 may be joined with the adjacent nitrogen atom to form a nitrogen-containing heterocyclic ring which may be substituted); R2 and R3, which are identical or different, each represent a hydrogen atom, a halogen atom, a halo-lower alkyl group, a lower alkyl group, a lower alkynyl group, a lower alkoxy group, a cyano group, a lower alkanoyl group or a lower alkylsulfonyl group; A represents a benzene ring or a heterocyclic ring; D represents a single bond or methylene; m represents an integer from 1 to 3, and n represents an integer from 1 to 5 (with the proviso that the case where R1 is an ethoxy group, R2 is a 2,4-dichloro group, R3 is a hydrogen atom, A is a benzene ring, and D is methylene; and the case where R1 is an ethoxy group, R2 is a 2,4-dichloro group, R3 is a hydrogen atom, a 2-methyl group, a 4-methyl group, a 4-methoxy group or a 4-ethoxy group, A is a benzene ring, and D is a single bond, are excluded).