2475-68-5

Upstream product

• 1421739-78-7 2-[(benzyloxyimino)]-N-(4-tert-butylphenyl)acetamide 
• 769-92-6 4-tert-Butylaniline 

Downstream Products

• 1424209-44-8 9-tert-butyl-4,5,6,7-tetraphenylazepino[3,2,1-hi]indole-1,2-dione 
• 2475-77-6 2-amino-5-(1,1-dimethylethyl)benzoic acid 
• 1388642-19-0 methyl 5-fluoro-2-{[(4-methylphenyl)sulfonyl]amino}benzoate 

Relevant academic research and scientific papers

Synthesis of New tert-Butyl- and Bromo-functionalized [1,2,4]Triazino [5,6-b]indole-3-thiols and Indolo[2,3-b]quinoxalines

In the present investigation, the synthesis of a series of structurally new and interesting tert-butyl- and bromo-functionalized [1,2,4]triazino[5,6-b]indoles (6a–f) and indolo[2,3-b]quinoxalines (8a–f) has been achieved, involving the condensation reacti

First synthesis of tert-butyl-substituted [1,2,4]triazino[5,6-b]indole-3-thiols and indolo[2,3-b]quinoxalines

In this investigation, the first introduction of a tert-butyl group into [1,2,4]triazino[5,6-b]indole and indolo[2,3-b]quinoxaline systems, leading to a series of structurally novel 8-(t-butyl)-5H-[1,2,4]triazino[5,6-b]indole-3-thiol and 9-(t-butyl)-6H-indolo[2,3-b]quinoxaline derivatives, has been achieved by condensation of tert-butyl-substituted isatins with benzene-1,2-diamine or thiosemicarbazide. The molecular structures of these newly synthesized compounds were elucidated on the basis of elemental analysis and spectral data.

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

Oxidative fluorination of N-arylsulfonamides

We report a late stage oxidative nucleophilic fluorination of N-arylsulfonamides, a class of compounds so far not considered as precursors to 4-fluorophenyl sulfonamides. By installing a para-positioned tert-butyl substituent on the aniline, oxidative fluorination takes place regioselectively in the presence of HF·pyridine and PIDA. This methodology has been shown to give good yields for a variety of ortho- and meta-functionalised N-arylsulfonamides and has been adapted for radiofluorination to give 4-[18F]fluorophenyl sulfonamides under carrier added conditions.

Synthesis of substituted isatins

Isatins are valuable intermediates for heterocyclic chemistry. Most of the common methods for their production are less than adequate when the number and lipophilicity of substituents on the targeted isatin are increased. Our group desired such molecules

ORGANIC COMPOUNDS

The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.