247592-09-2Relevant academic research and scientific papers
Use of tetrabenzo[a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of the quinolone antibacterial, ciprofioxacin
Hay, Alastair M.,Hobbs-Dewitt, Sheila,MacDonald, Alasdair A.,Ramage, Robert
, p. 1979 - 1985 (1999)
The affinity of tetrabenzo[a,c,g,i]fluorene (Tbf) for charcoal has been applied successfully to provide an alternative to existing solid phase synthesis methodology. In a synthesis of the quinolone antibacterial, Ciprofloxacin, traditional solution phase synthesis has been coupled with efficient pseudo-solid phase purification.
Support for synthesis and purification of compounds
-
, (2008/06/13)
A method for the preparation and purification of compounds using a novel support, a tetrabenzo[a,c,g,i]fluorene group (Tbf) comprising reacting a building block (A) containing a Tbf group (Tbf-A), with a second building block (B), to afford an intermediate compound (Tbg-A-B) followed by purifying the intermediate compound by adsorption on a carbon support, removing the intermediate compound from the support with a solvent and repeating the previous reactions using the required number of building blocks to synthesize the compounds followed by removal of the Tbf group to afford the desired compounds.
