24765-57-9

Usage

Uses

2,2-Di-n-butyl-1,3-propanediol is used as pharmaceutical intermediates.

InChI:InChI=1/C11H24O2/c1-3-5-7-11(9-12,10-13)8-6-4-2/h12-13H,3-10H2,1-2H3

Upstream product

• 101853-00-3 diethyl-malonic acid dibutyl ester 
• 124-38-9 carbon dioxide 
• 596-75-8 diethyl dibutylmalonate 

Downstream Products

• 1373485-62-1 8-(4-(diphenylamino)styryl)-3,3-dibutyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine-6-carbaldehyde 
• 1373485-53-0 3,3-dibutyl-6-((E)-2-(5-hexylthiophen-2-yl)vinyl)-3,4-dihydro-8-(5,5-dimethyl-1,3-dioxan-2-yl)-2H-thieno[3,4-b][1,4]dioxepine 
• 100453-54-1 5,5-dibutyl-dihydro-[1,3]oxazine-2,4-dione 
• 109820-93-1 2-Hydroxymethyl-2-butyl-hexanol-mono-<4-brom-benzolsulfonat> 
• 102887-77-4 2-Hydroxymethyl-2-butyl-hexanol-bis-<4-brom-benzolsulfonat> 

Relevant academic research and scientific papers

Electron transfer reduction of unactivated esters using SmI 2-H2O

The reduction of unactivated esters using samarium diiodide is reported for the first time. The optimised protocol allows for the reduction of primary, secondary and tertiary alkyl esters in excellent yields and is competitive with reductions mediated by metal hydrides and alkali metals.

Novel benzothiepines having activity as inhibitors of lleal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides

A process for preparing enantiomerically enriched tetrahydrobenzothipeine oxides comprises cyclizing an enantiomerically enriched aryl-3-propanalsulfoxide wherein the sulfur atom of the aryl-3-propanalsulfoxide is a chiral center.

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Synthesis and Properties of New Lipophilic Macrotricyclic Cylindrical Cryptands

Cylindrical cryptands 2a-c, in which two 1,7-dioxa-4,10-diazacyclododecane rings are connected by two equally substituted propylene bridges, have been obtained in appreciable yields by a ''one-pot'' synthesis.The assembling of the macrotricyclic structure is likely driven by the template effect of metal cations.These compounds, both as free receptors or as complexes, exist as cis and trans diastereoisomers, which do not interconvert and have been separated and characterized by X-ray analysis.The extraction constants (Ke) of cryptands 2 for alkali picrates under CHCl3/H2O and solid/liquid two-phase conditions have been measured by UV-vis spectrophotometry.The complexation behavior of cryptands 2 has been rationalized analyzing the preorganization of binding sites in the minimum energy conformations obtained by molecular mechanics calculations.Minimum energy conformations have been calculated also for the previously reported cryptands 1 and have been compared with those of 2.Results fit reasonably well with those of X-ray structures.