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Usage

Uses

Used in Pharmaceutical Research:
4-IODO-3,5-DIPHENYLISOXAZOLE is used as a building block for the development of new compounds with potential biological activity, particularly in the creation of pharmaceuticals with therapeutic applications.
Used in Organic Synthesis:
4-IODO-3,5-DIPHENYLISOXAZOLE is used as a key intermediate in organic synthesis, facilitating the production of various compounds with diverse applications.
Used in Agrochemicals:
4-IODO-3,5-DIPHENYLISOXAZOLE is used as a component in the development of agrochemicals, contributing to the creation of effective products for agricultural use.
Used in Research and Industrial Applications:
4-IODO-3,5-DIPHENYLISOXAZOLE is used as a versatile chemical compound in research and industrial applications, providing a foundation for the production of materials with specific properties and functions.
Overall, 4-IODO-3,5-DIPHENYLISOXAZOLE's unique structure and properties make it a valuable asset in various industries, with significant potential for further study and application in the fields of chemistry and pharmacology.

Upstream product

• 7338-94-5 1,3-diphenyl-2-propynone 
• 98-88-4 benzoyl chloride 
• 536-74-3 phenylacetylene 
• 29881-14-9 1,2-diphenyl-cyclopropane 
• 870127-38-1 (Z)-1,3-diphenylprop-2-yn-1-one O-methyl oxime 
• 2039-49-8 3,5-diphehylisoxazole 

Downstream Products

• 2039-49-8 3,5-diphehylisoxazole 
• 1374745-80-8 3,5-diphenyl-4-(trifluoromethanesulfonyl)isoxazole 
• 10557-78-5 3,5-diphenyl-4-bromoisoxazole 
• 10557-79-6 4-chloro-3,5-diphenylisoxazole 
• 2289-55-6 methyl [3,5-diphenylisoxazol-4-yl]carboxylate 

Relevant academic research and scientific papers

R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond

A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

Synthesis of C4-alkynylisoxazoles: Via a Pd-catalyzed Sonogashira cross-coupling reaction

A Pd-catalyzed Sonogashira cross-coupling reaction for the synthesis of C4-alkynylisoxazoles from 3,5-disubsitituted-4-iodoisoxazoles and terminal alkynes was described, which could afford the corresponding products with high yield (up to 98%). The result

Isomerizable (: E / Z)-alkynyl- O -methyl oximes employing TMSCl-NCS in chlorinative cyclization for the direct synthesis of 4-chloroisoxazoles

For the first time, 4-chloroisoxazoles are directly synthesized in moderate to excellent yields from (E/Z)-alkynyl-O-methyl oximes via chlorinative cyclization. The synthesis employs the combination of N-chlorosuccinimide (NCS) and chlorotrimethylsilane (

The synthesis of highly substituted isoxazoles by electrophilic cyclization: An efficient synthesis of valdecoxib

(Chemical Equation Presented) A large number of functionally substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence of ICl to give the corresponding 4-iodoisoxazoles in moderate to excellent yields. The resulting 4-iodoisoxazoles undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles, including valdecoxib.

Synthesis of isoxazoles via electrophilic cyclization

(Chemical Equation Presented) A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICI, I2, Br2,

Convenient and improved halogenation of 3,5-diarylisoxazoles using N-halosuccinimides

The convenient C-4 halogenation of 3,5-diarylisoxazoles using N-halosuccinimides (NBS, NCS, or NIS) in acetic acid is described. A strong acid catalyst was required for efficient halogenation of some isoxazoles depending on the substituent on the 5-phenyl ring. Finally, the 4-iodoisoxazoles were found to undergo a novel proto-deiodination upon heating in the presence of H2SO4.