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24781-50-8

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24781-50-8 Usage

Description

3-(NAPHTHALEN-1-YL)PROPAN-1-AMINE, also known as beta-naphthylpropylamine, is a chemical compound derived from naphthalene and classified as an amine. It is a colorless to pale yellow liquid with a strong amine odor, insoluble in water, and soluble in most organic solvents. This versatile chemical intermediate is utilized in the synthesis of various organic compounds, including pharmaceuticals and dyes.

Uses

Used in Pharmaceutical Industry:
3-(NAPHTHALEN-1-YL)PROPAN-1-AMINE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the development of new drugs, potentially enhancing their efficacy and therapeutic properties.
Used in Dye Industry:
In the dye industry, 3-(NAPHTHALEN-1-YL)PROPAN-1-AMINE is used as a chemical intermediate for the production of dyes. Its ability to form stable compounds with other molecules contributes to the creation of dyes with specific color properties and improved performance characteristics.
Used in Organic Compounds Synthesis:
3-(NAPHTHALEN-1-YL)PROPAN-1-AMINE is used as a building block in the synthesis of other organic compounds. Its reactivity and compatibility with various organic solvents make it a valuable component in the development of new chemical entities for various applications.
It is crucial to handle 3-(NAPHTHALEN-1-YL)PROPAN-1-AMINE with care due to its potential harmful effects if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be implemented during its use to ensure the well-being of individuals and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 24781-50-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,7,8 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24781-50:
(7*2)+(6*4)+(5*7)+(4*8)+(3*1)+(2*5)+(1*0)=118
118 % 10 = 8
So 24781-50-8 is a valid CAS Registry Number.

24781-50-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-naphthalen-1-ylpropan-1-amine

1.2 Other means of identification

Product number -
Other names 3-(1-naphthyl)propylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24781-50-8 SDS

24781-50-8Downstream Products

24781-50-8Relevant articles and documents

Studies on the solvent dependence of the carbamic acid formation from ω-(1-naphthyl)alkylamines and carbon dioxide

Masuda, Koji,Ito, Yoshikatsu,Horiguchi, Masahiro,Fujita, Haruo

, p. 213 - 229 (2005)

Carbamic acid formation from amine and carbon dioxide in a variety of solvents was investigated by measuring NMR (1H, 13C, HMBC) and IR spectra in situ. Bubbling of CO2 through solutions of naphthylalkylamines 1-3 in DMSO, DMF or pyridine (protophilic, highly dipolar, aprotic solvent) resulted in complete conversion of the amines to the corresponding carbamic acids 4-6. In dioxane (protophilic, dipolar, aprotic solvent), the carbamic acid and a small amount of the ammonium carbamate were formed. By contrast, in MeCN (protophobic, dipolar, aprotic solvent), in benzene or CHCl3 (apolar, aprotic solvent), or in 2-PrOH or MeOH (dipolar, amphiprotic solvent), ammonium carbamates 7-9 rather than 4-6 were formed, although the ammonium bicarbonates/carbonates were competitively formed in MeOH. The ammonium carbamates precipitated in many cases and hence they could be separated. The selective generation of the undissociated carbamic acids in preference to the ammonium carbamates in protophilic, dipolar, aprotic solvents (DMSO, DMF, pyridine, and dioxane) is rationalized by considering the acid-base equilibria between the amines 1-3 and the carbamic acids 4-6 in nonaqueous media. The obtained selectivity is likely due to the larger pKa values for 4-6 than the amines 1-3 in these solvents. Interestingly, the fluorescence intensities for 1-3 were dramatically enhanced (4-50 times) in DMSO or DMF upon introduction of CO2, while they were not altered very much in dioxane, MeCN, benzene, CHCl3, 2-PrOH, and MeOH, except small to medium increases (1.3-3 times) for 1 in dioxane, MeCN, 2-PrOH and MeOH. As a whole, the solvent effects observed in these fluorescence studies are consistent with those observed in the above NMR and IR studies. Finally, methoxycarbonylation of amine 3 into the methyl carbamate was successfully accomplished by using (trimethylsilyl)diazomethane in the presence of CO 2. Probably due to pKa(6)>pKa(3) in protophilic dipolar aprotic solvents, the conversion 3→6 is nearly complete while the formation of 9 is minimal.

Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain

Furet, Pascal,Gay, Brigitte,Caravatti, Giorgio,García-Echeverría, Carlos,Rahuel, Joseph,Schoepfer, Joseph,Fretz, Heinz

, p. 3442 - 3449 (1998)

The X-ray structure of the Grb2-SH2 domain in complex with a specific phosphopeptide ligand has revealed the existence of an extended hydrophobic area adjacent to the primary binding site of the ligand on the SH2 domain. This has been exploited to design hydrophobic C-terminal groups that improve the binding affinity of the minimal sequence pTyr-Ile-Asn recognized by the Grb2-SH2 domain. The most significant increase in affinity (25-fold compared to that of the reference peptide having a nonsubstituted carboxamide C- terminus) was obtained with a 3-naphthalen-1-yl-propyl group which was predicted to have the largest contact area with the SH2 domain hydrophobic region. This modification combined with replacement of the minimal sequence isoleucine residue by 1-aminocyclohexane carboxylic acid to stabilize the β- turn conformation required for recognition by the Grb2-SH2 domain resulted in the high affinity (47 nM in an ELISA assay) and selective phosphopeptide Ac- pTyr-Ac6c-Asn-NH(3-naphthalen-1-yl-propyl).

A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure-activity relationships

Nomura, Takashi,Iwaki, Tsutomu,Yasukata, Tatsuro,Nishi, Koichi,Narukawa, Yukitoshi,Uotani, Koichi,Hori, Toshihiko,Miwa, Hideaki

, p. 6615 - 6628 (2007/10/03)

A new type of ketolides, bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether and a cyclic carbonate at the C-11,12 position was prepared and the antibacterial activities of the compounds were evaluated. Some of the derivatives showed potent ant

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