247913-67-3Relevant academic research and scientific papers
N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
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Page column 12, (2010/02/10)
Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), R1 and R2=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R3=H, —CO-Alkyl, or —CO-Aryl, R4/
Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: Structure-activity relationship of antagonists of (6R)-5,6,7,8- tetrahydrobiopterin cofactor
Fr?hlich, Lothar G.,Kotsonis, Peter,Traub, Hermann,Taghavi-Moghadam, Shahriyar,Al-Masoudi, Najim,Hofmann, Heinrich,Strobel, Hartmut,Matter, Hans,Pfleiderer, Wolfgang,Schmidt, Harald H. H. W.
, p. 4108 - 4121 (2007/10/03)
The family of nitric oxide synthases (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important cellular messenger molecule which has been implicated in the pathophysiology of septic shock and inflammatory and neurode
