24799-62-0Relevant articles and documents
Identification and optimization of inhibitors of trypanosomal cysteine proteases: Cruzain, rhodesain, and TbCatB
Mott, Bryan T.,Ferreira, Rafaela S.,Simeonov, Anton,Jadhav, Ajit,Ang, Kenny Kean-Hooi,Leister, William,Shen, Min,Silveira, Julia T.,Doyle, Patricia S.,Arkin, Michelle R.,McKerrow, James H.,Inglese, James,Austin, Christopher P.,Thomas, Craig J.,Shoichet, Brian K.,Maloney, David J.
supporting information; experimental part, p. 52 - 60 (2010/04/29)
Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas' disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival: cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A rec