13734-08-2

Usage

Physical form

white to off-white crystalline solid

Melting point

155-159°C

Stability

stable under normal conditions of use and storage

Uses

reagent for the synthesis of peptides and nucleotides, coupling agent in organic synthesis and chemical reactions, facilitator in the formation of amide bonds, production of pharmaceuticals, agrochemicals, and specialty chemicals

Toxicity

can be toxic if ingested or inhaled

Safety precautions

should be handled and stored with proper safety precautions in place

Role in industry

crucial in chemical and pharmaceutical industries as a versatile reagent in organic synthesis processes.

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 141-43-5 ethanolamine 

Downstream Products

• 24799-62-0 2-(4-anilino-6-chloro-[1,3,5]triazin-2-ylamino)-ethanol 

Relevant academic research and scientific papers

Double base compound based on phosphonitrile and triazine group and preparation method of double base compound

The invention discloses a double base compound based on phosphonitrile and triazine group. A preparation method of the double base compound comprises the following steps: introducing a triazine group into phosphonitrilic chloride trimer with intrinsically flame retardant property, and substituting six chlorine atoms on the side chains; further introducing a compound containing diamido or dyhydroxyl into the side chains of the triazine group, so as to obtain the double base compound based on phosphonitrile and triazine group. The compound is enriched in elements N and P; because the compound simultaneously contains the phosphonitrile and triazine group, the compound can achieve a flame-retardant effect in the combustion process by virtue of gas phase flame retardance and condensed phase mechanisms and has an excellent char-forming effect, and the generated carbon layer has the effects of insulating heat and inhibiting oxygen and achieves the effects of intumescent flame retardants. In addition, the phosphonitrile and triazine group have a synergistic flame retardant effect in the matrix combustion process. Moreover, the compound is high in heat stability, char-forming rate and processability and can be widely applied to flame-retardant modification of various high polymer materials.

Cytochrome P450-catalyzed dealkylation of atrazine by Rhodococcus sp. strain NI86/21 involves hydrogen atom transfer rather than single electron transfer

Cytochrome P450 enzymes are responsible for a multitude of natural transformation reactions. For oxidative N-dealkylation, single electron (SET) and hydrogen atom abstraction (HAT) have been debated as underlying mechanisms. Combined evidence from (i) product distribution and (ii) isotope effects indicate that HAT, rather than SET, initiates N-dealkylation of atrazine to desethyl- and desisopropylatrazine by the microorganism Rhodococcus sp. strain NI86/21. (i) Product analysis revealed a non-selective oxidation at both the αC and βC-atom of the alkyl chain, which is expected for a radical reaction, but not SET. (ii) Normal 13C and 15N as well as pronounced 2H isotope effects (εcarbon: -4.0‰ ± 0.2‰; εnitrogen: -1.4‰ ± 0.3‰, KIEH: 3.6 ± 0.8) agree qualitatively with calculated values for HAT, whereas inverse 13C and 15N isotope effects are predicted for SET. Analogous results are observed with the Fe(iv)O model system [5,10,15,20-tetrakis(pentafluorophenyl)porphyrin-iron(iii)- chloride + NaIO4], but not with permanganate. These results emphasize the relevance of the HAT mechanism for N-dealkylation by P450.

Identification and optimization of inhibitors of trypanosomal cysteine proteases: Cruzain, rhodesain, and TbCatB

Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas' disease and African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases for survival: cruzain for T. cruzi and TbCatB/rhodesain for T. brucei. A rec