24808-79-5Relevant academic research and scientific papers
1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates
Sun, Xianwei,Admane, Prasad,Starosolski, Zbigniew A.,Eriksen, Jason L.,Annapragada, Ananth V.,Tanifum, Eric A.
, (2021/11/10)
The development of imaging agents for in vivo detection of alpha-synuclein (α-syn) pathologies faces several challenges. A major gap in the field is the lack of diverse molecular scaffolds with high affinity and selectivity to α-syn fibrils for in vitro s
Highly diastereoselective spiro-cyclopropanation of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides
Huang, Jie,Lee, Kevin,Ma, Ping,Sun, Shaofa,Wang, Gangqiang,Wang, Jian,Wu, Yang,Xing, Yalan
supporting information, p. 18776 - 18780 (2021/10/26)
A highly diastereoselective spiro-cyclopropanation reaction of 2-arylidene-1,3-indanediones and dimethylsulfonium ylides has been developedviabase-induced annulation. This efficient and simple protocol features simple operations, mild conditions and excellent functional group compatibility. A variety of structurally interesting spiro-cyclopropanes were prepared in excellent yields and diastereomeric ratios (up to 97% yield and 20?:?1 dr). Also, ring expansion of the cyclopropanation product to quickly deliver a complex indeno[1,2-c]pyridazine structure showcased an interesting application of this method.
Lewis Acid Triggered Vinylcyclopropane-Cyclopentene Rearrangement
Ivanova, Olga A.,Chagarovskiy, Alexey O.,Shumsky, Alexey N.,Krasnobrov, Vasiliy D.,Levina, Irina I.,Trushkov, Igor V.
, p. 543 - 560 (2018/01/27)
We report a mild Lewis acid induced isomerization of donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse electron-withdrawing group(s) at the adjacent positions, into substituted cyclopentenes. We have found that 1,1,2-trisubstituted cy
Diastereoselective Synthesis of Functionalized Angularly-Fused Tetracycles via an Organocatalytic Quadruple Reaction Sequence
Chang, Fu-Jie,Gurubrahamam, Ramani,Chen, Kwunmin
supporting information, p. 1277 - 1282 (2017/04/18)
An efficient diastereoselective strategy to access complex structural tetracycles was described through an organocascade quadruple reaction sequence between (E)-2-(3-arylallylidene)-1H-indene-1,3(2H)-diones and β-keto esters. The reaction proceeded throug
A study on the reaction of 1,3-indandione with Schiff bases: Synthesis of new 1,3-indandiones with expected psychopharmacological and anticoagulant activity
Afsah,Etman,Hamama,Sayed-Ahmed
, p. 244 - 248 (2007/10/03)
Condensation of the title compound 1 with aldimines gave the 2-arylidene derivatives 3-9 instead of the expected Mannich bases 2. Compounds 10-11 were obtained from 1 and aldimines of α-ketoaldehydes. Isatin-anil (12) reacts with 1 to give 13. However, th
