24813-13-6

Basic information

• Product Name: N,N-bis(2-chloroethyl)-3-nitroaniline
• CAS NO: 24813-13-6
• Molecular Formula: C₁₀H₁₂Cl₂N₂O₂
• Molecular Weight: 263.1205
• Mol File: 24813-13-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 387.4°C at 760 mmHg
• Flash Point: 188.1°C
• Density: 1.348g/cm³
• Vapor Pressure: 3.3E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: N,N-bis(2-chloroethyl)-3-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-chloroethyl)-3-nitroaniline(24813-13-6)
• EPA Substance Registry System: N,N-bis(2-chloroethyl)-3-nitroaniline(24813-13-6)

Safety Data

• Hazardous Substances Data: 24813-13-6(Hazardous Substances Data)

Upstream product

• 24812-82-6 3-[N,N-Bis(2-hydroxyethyl)amino]nitrobenzene 
• 22974-35-2 N,N-bis(2-(methylsulfonyloxy)ethyl)-3-nitroaniline 
• 99-09-2 3-nitro-aniline 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 13686-19-6 N¹,N¹-bis(2-chloroethyl)benzene-1,3-diamine 
• 1456621-47-8 N¹,N¹-bis(2-chloroethyl)-N³-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,3-diamine 
• 1456621-45-6 4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-ol 
• 1456621-43-4 4-(3-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride 
• 1447828-82-1 N¹-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N³,N³-bis(2-chloroethyl)benzene-1,3-diamine hydrochloride 
• 1456621-38-7 N¹,N¹-bis(2-chloroethyl)-N³-(6,7-dimethoxyquinazolin-4-yl)benzene-1,3-diamine hydrochloride 
• 13686-10-7 N,N-bis(2-chloroethyl)-1,3-phenylenediamine hydrochloride 
• 27921-76-2 2-Benzyloxycarbonylamino-3-{3-[bis-(2-chloro-ethyl)-amino]-phenylcarbamoyloxy}-propionic acid benzyl ester 
• 28021-82-1 2-{3-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyloxy}-benzoic acid benzyl ester 
• 27884-91-9 3-{3-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyloxy}-benzoic acid methyl ester 
• 27884-90-8 {3-[Bis-(2-chloro-ethyl)-amino]-phenyl}-carbamic acid 4-cyclohexyl-phenyl ester 
• 27884-92-0 3-{3-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyloxy}-benzoic acid 
• 27884-89-5 Phenyl-N-m-(bis-2-chlorethylamino)-phenylcarbamat 
• 27885-47-8 Isopropyl-N-m-(bis-2-chlorethylamino)-phenylcarbamat 

Relevant articles and documents

Pyrazolo [1, 5 - a] pyrimidine nitrogen mustard derivative and its preparation method and tumor therapeutic use

The invention relates to pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives or medical salts thereof, as well as application of the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives or the medical salts thereof. The pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives and the medical salts thereof have the structure shown as the formula I. Pharmacological experiments show that the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives and the medical salts thereof have inhibiting effects on the proliferation of various tumor cells. Moreover, the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives are small in toxicity, have the advantages of selectivity on tumor cells, and are dual-functional anti-tumor drugs. Meanwhile, the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives are easy to synthesize, and the overall yields are high. All the advantages show that the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives have great potential of being anti-tumor drugs.

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.

Phenylbenzimidazole derivatives

Described herein is an anticancer agent, an antiviral agent or an antimicrobial agent which contains, as an active ingredient for acting on DNA, a compound presented by the following formula (1) or its pharmacologically acceptable salt: STR1