248265-11-4Relevant academic research and scientific papers
Synthetic approaches toward the marine alkaloid prenostodione
Badenock, Jeanese C.,Jordan, Jason A.,Gribble, Gordon W.
, p. 2759 - 2762 (2013)
An efficient synthesis of the core of prenostodione (3) is described herein featuring the base condensation of BOC-protected indole diesters 21 and 24 with p-methoxybenzaldehyde (22) and 4-[(t-butyldimethylsilyl)oxy]benzaldehyde (26). Attempts at selective saponification of the resultant diesters yielded isoprenostodione (3a) bearing the ester functionality at the C-3 position of the indole ring.
Synthesis of 6-substituted 5,6,7,12-tetrahydrobenzo[4,5]- cyclohept[b]indol-12-one derivatives
Mouaddib, Abderrahim,Joseph, Benoit,Hasnaoui, Aissa,Merour, Jean-Yves,Leonce, Stephane
, p. 2127 - 2137 (2007/10/03)
The synthesis of 6-substituted 5,6,7,12- dihydrobenzo[4,5]cyclohept[b]indole derivatives, through a regioselective alkylation of 1 in position-6, is reported. The antiproliferative activity of 18 was evaluated.
