248275-65-2

Upstream product

• 248275-64-1 2-Cyclopent-3-enylmethyl-3,4-difluoro-phenol 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 20145-35-1 (3-cyclopenten-1-yl)-methanone 
• 115144-40-6 1,2-difluoro-4-methoxy-benzene 
• 248275-62-9 cyclopent-3-enyl-(2,3-difluoro-6-methoxy-phenyl)-methanol 
• 248275-63-0 2-Cyclopent-3-enylmethyl-3,4-difluoro-1-methoxy-benzene 

Downstream Products

• 922166-24-3 (+)-N-benzyl-5,6-difluoro-11-azatricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene 

Relevant academic research and scientific papers

Enantioselective synthesis of nicotinic receptor probe 7,8-difluoro-1,2,3, 4,5,6-hexahydro-1,5-methano-3-benzazocine

(Chemical Equation Presented) The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and an enantioselective cyclization to establish a compound with the key [3.2.1]-bicyclic core, 29.