248278-47-9

Upstream product

• 16210-64-3 2-(4-fluorophenylmethylene)-1H-indane-1,3-dione 
• 123-54-6 acetylacetone 

Downstream Products

• 248278-55-9 1-(4-fluoro-phenyl)-2-(6-phenyl-2-thioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-1,4-dihydro-2H-fluorene-3,9-dione 
• 1026840-86-7 1-(4-fluoro-phenyl)-2-(3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-7-yl)-1,4-dihydro-2H-fluorene-3,9-dione 
• 248278-51-5 1-(4-fluoro-phenyl)-2-(3-phenyl-acryloyl)-1,4-dihydro-2H-fluorene-3,9-dione 

Relevant academic research and scientific papers

Synthesis and reactions of some new 5-aryl-3-oxo-7-(4'-aryl-2',5'-dioxo- 1',2',3,'4'-tetrahydrofluoren-3'-yl)-5h, 8h-2,3-dihydrothiazolo[5,4- b]pyrimidines of expected biological activity

2-Arylidene-indane-1,3-dione 1 on treatment with acetyl acetone in gl. acetic acid gives 3-acetyl-4-aryl-2,5-dioxo-1,2,3,4-tetrahydrofluorenes 2a-d which on reaction with benzaldehyde yield 4-aryl-3-cinnamoyl-2, 5-dioxo- 1, 2, 3, 4-tetrahydrofluorenes 3a-d. Compounds 3a-d when reacted with thiourea in gl. CH3COOH/Ac2O in the presence of anhyd, sodium acetate afford 4,5- diaryl-6-(4'-aryl-2', 5'-dioxo-1', 2', 3', 4'-tetrahydrofluoren-3'-yl)-1, 2, 3,4-tetrahydropyrimidine-2-thiones 4a-d which on treatment with chloroacetic acid furnish 5-aryl-3-oxo-7-(4'-aryl-2',5'-dioxo-1',2',3',4'- tetrahydrofluoren-3'-yl)-5H, 8H-2,3-dihydrothiazolo[5,4-b]pyrimidines 5a-d. Compounds 5a-d on condensation with benzaldehyde yield 2-arylmethylene-3-oxo- 5- phenyl-7-(4'-aryl-2', 5'-dioxo-1', 2', 3', 4'-tetrahydrofluoren-3'- yl)- 5H, 8H-2,3-dihydrothiazolo[5,4-b]pyrimidines 6a-d.