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L-Methionine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester is a complex organic compound with the chemical formula C20H20N2O6S. It is a derivative of the essential amino acid L-methionine, where the amino group is protected by a phenylmethoxycarbonyl (PMC) group, and the carboxylic acid group is esterified with a 4-nitrophenol moiety. L-Methionine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester is often used in peptide synthesis as a protected form of L-methionine, allowing for the controlled addition of the amino acid to growing peptide chains. The PMC group serves as a temporary protecting group that can be selectively removed under mild conditions, while the 4-nitrophenyl ester group is used for monitoring the progress of the reaction due to its characteristic absorbance at 400 nm. The synthesis and use of L-Methionine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester are crucial in the field of biochemistry and pharmaceuticals for the development of new drugs and therapeutics.

2483-42-3

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2483-42-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2483-42-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2483-42:
(6*2)+(5*4)+(4*8)+(3*3)+(2*4)+(1*2)=83
83 % 10 = 3
So 2483-42-3 is a valid CAS Registry Number.

2483-42-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name benzyloxycarbonyl-L-methionine p-nitrophenyl ester

1.2 Other means of identification

Product number -
Other names N-carbobenzoxy-L-methionine p-nitrophenyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2483-42-3 SDS

2483-42-3Relevant academic research and scientific papers

Coordination compounds of tripeptides and pentapeptides containing L-histidyl residues. Studies towards structural modes for the active site of copper proteins

Hulsbergen, F. B.,Reedijk, J.

, p. 278 - 286 (2007/10/02)

Five small, completely protected, L-histidyl(NτBzl)-containing peptides, were synthesized and characterized by NMR spectroscopy, i.e., R-Ala-His(Nτ-Bzl)-Ala-R' (1), R-His(Nτ-Bzl)-Ala-Ala-Ala-Met-R' (2), R-His(Nτ-Bzl)-Ala-Ala-Ala-His(Nτ-Bzl)-R' (3), R-His(Nτ-Bzl)-Ala-His(Nτ-Bzl)-Ala-His(Nτ-Bzl)-R' (4), R-His(Nτ-Bzl)-Ala-His(Nτ-Bzl)-R' (5), in which: R is phenylacetyl (PhCH2CO-, R' is phenylamino (-NHPh); Bzl is benzyl (PhCH2-).It has been shown that benzylation of histidine residues takes place at the Nτ atom of the imidazole.The resulting peptide derivatives appear to be good ligands for CoII, ZnII and CuI.Titrations of zinc chloride solutions towards peptide solutions (in dmso-d6, dimethyl sulfoxide followed by NMR spectroscopy show the formation of the two species ?His)2Cl2> and ?His)(dmso)Cl2>.Copper(I)-chloride titrations result in formation of trigonal planar and tetrahedral complexes (in dmso-d6).Zinc, copper and cobalt trifluoromethanesulfonates were also investigated, and corresponding tetrahedral species with additional dmso ligands replacing chloride were obtained.In addition, octahedral complexes have been found, as shown for cobalt(II) using ligand-field spectroscopy.Conductivity experiments of zinc chloride complexes in dmso and chloroform indicate non-electrolytes.Their very low conductivity in methanol indicates only slight dissociation of chloride, in agreement with a tetrahedral geometry for zinc(II).For ?His)2Cl2>, the UV-VIS adsorption spectra in dmso and in the solid state (diffuse reflection) are comparable, indicating tetrahedral geometry, with a CoN2Cl2 chromophore.

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