2485-33-8

Basic information

• Product Name: H-(2S,4R)-GAMMA-HYDROXY-GLU-OH
• Synonyms: (S)-2-AMINO-[(R)-4],5-DIHYDROXY-OXOPENTANOIC ACID;H-(2S,4R)-GAMMA-HYDROXY-GLU-OH;H-(2S,4R)-GLU(GAMMA-OH)-OH;(2S,4R)-GAMMA-HYDROXY-GLUTAMIC ACID;H-(2S,4R)-g-Hydroxy-Glu-OH;(2S,4R)-2-Amino-4-hydroxypentanedioic acid;(2S,4R)-4-Hydroxy-L-glutaMic Acid;(2S,4R)-g-4-Hydroxy-L-glutaMic Acid
• CAS NO: 2485-33-8
• Molecular Formula: C5H9NO5
• Molecular Weight: 163.13
• Mol File: 2485-33-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 458.7 °C at 760 mmHg
• Flash Point: 231.2 °C
• Appearance: /
• Density: 1.595 g/cm³
• Storage Temp.: -15°C
• Solubility: DMSO (Slightly), Water (Slightly)
• PKA: 2.15±0.10(Predicted)
• Stability: Hygroscopic
• BRN: 1725871
• CAS DataBase Reference: H-(2S,4R)-GAMMA-HYDROXY-GLU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-(2S,4R)-GAMMA-HYDROXY-GLU-OH(2485-33-8)
• EPA Substance Registry System: H-(2S,4R)-GAMMA-HYDROXY-GLU-OH(2485-33-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2485-33-8(Hazardous Substances Data)

Usage

Uses

(2S,4R)-4-Hydroxy-L-glutamic Acid is a metabolite of Glutamic acid (G596960).

Upstream product

• 3674-13-3 2,3-dibromopropionic acid ethyl ester 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 67359-78-8 4,5-dihydro-isoxazole-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 51163-84-9 (+/-)-threo-4-hydroxy-glutamic acid-1-lactone; hydrochloride 
• 127-17-3 2-oxo-propionic acid 
• 298-12-4 Glyoxilic acid 
• 1187-99-1 4-hydroxy-2-oxoglutaric acid 
• 198133-06-1 Dimethyl ester of 4-bromo-N-phthalyl-L-glutamic acid 

Relevant articles and documents

Synthesis and properties of 4-haloglutamates

Synthesis of stereoisomers of 4-bromo- and 4-iodo-N-phthaloylglutamates based on the bromination of N-phthaloylglutamic acid followed by separation of diastereoisomers is described.

Synthesis of 4,4-Disubstituted L-Glutamic Acids by Enzymatic Transamination

The syntheses of optically pure 4,4-dimethyl-L-glutamic acid as well as (2S,4R)- and (2S,4S)-4-hydroxy-4-methylglutamic acids have been achieved by transamination of the corresponding 2-oxo-4,4-dimethyl- and rac-2-oxo-4-hydroxy-4-methylglutaric acids using glutamic oxalacetic transaminase (GOT).