2485-33-8Relevant academic research and scientific papers
Synthesis and properties of 4-haloglutamates
Krasnow,Bukrina,Zhdanova,Kodess,Korolyova
, p. 961 - 964 (1994)
Synthesis of stereoisomers of 4-bromo- and 4-iodo-N-phthaloylglutamates based on the bromination of N-phthaloylglutamic acid followed by separation of diastereoisomers is described.
Stereoselective synthesis of γ-hydroxy-α-amino acids through aldolase-transaminase recycling cascades
Guérard-Hélaine, Christine,Heuson, Egon,Ndiaye, Moussa,Gourbeyre, Léa,Lemaire, Marielle,Hélaine, Virgil,Charmantray, Franck,Petit, Jean-Louis,Salanoubat, Marcel,De Berardinis, Véronique,Gefflaut, Thierry
supporting information, p. 5465 - 5468 (2017/07/06)
Efficient bi-enzymatic cascades combining aldolases and α-transaminases were designed for the synthesis of γ-hydroxy-α-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination. l-syn or anti-4-hydroxyglutamic acid and d-anti-4,5-dihydroxynorvaline were thus prepared in 83-95% yield in one step from simple substrates.
Synthesis of 4,4-Disubstituted L-Glutamic Acids by Enzymatic Transamination
Helaine, Virgil,Rossi, Joel,Gefflaut, Thierry,Alaux, Sebastien,Bolte, Jean
, p. 692 - 697 (2007/10/03)
The syntheses of optically pure 4,4-dimethyl-L-glutamic acid as well as (2S,4R)- and (2S,4S)-4-hydroxy-4-methylglutamic acids have been achieved by transamination of the corresponding 2-oxo-4,4-dimethyl- and rac-2-oxo-4-hydroxy-4-methylglutaric acids using glutamic oxalacetic transaminase (GOT).
