1187-99-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-4-oxo-pentanedioic acid is used as an enzyme substrate for [application reason] its role as a 4-substituted analog of Glutamic acid, which makes it a good substrate for glutamic oxalacetic aminotransferase (GOT) [application type].
Used in Chemical Synthesis:
2-Hydroxy-4-oxo-pentanedioic acid is used as a chemical intermediate for [application reason] its unique structure and reactivity, which allows for the synthesis of various compounds and materials [application type].
Used in Cosmetics and Personal Care Industry:
2-Hydroxy-4-oxo-pentanedioic acid is used as a humectant and moisturizing agent for [application reason] its ability to retain moisture and improve the skin's hydration [application type].
Used in Food Industry:
2-Hydroxy-4-oxo-pentanedioic acid is used as a sweetener and humectant for [application reason] its sweetening properties and ability to retain moisture in the food products, enhancing their texture and shelf life [application type].
Used in Industrial Applications:
2-Hydroxy-4-oxo-pentanedioic acid is used as a component in the manufacturing of various products such as explosives, inks, and resins for [application reason] its versatile chemical properties and reactivity [application type].

InChI:InChI=1/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)

Upstream product

• 328-42-7 Oxalacetic acid 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 2485-33-8 (2S,4R)-4-hydroxyglutamic acid 
• 3913-68-6 threo-4-Hydroxy-L-glutamic acid 
• 3157-41-3 4-hydroxyglutamate 
• 82864-77-5 2,4-dihydroxy-glutaric acid 
• 91113-89-2 4-hydroxy-5-oxo-tetrahydro-furan-2-carboxylic acid 

Relevant academic research and scientific papers

Stereoselective synthesis of γ-hydroxy-α-amino acids through aldolase-transaminase recycling cascades

Efficient bi-enzymatic cascades combining aldolases and α-transaminases were designed for the synthesis of γ-hydroxy-α-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination. l-syn or anti-4-hydroxyglutamic acid and d-anti-4,5-dihydroxynorvaline were thus prepared in 83-95% yield in one step from simple substrates.

Process for producing an optically active gamma-hydroxy-L-glutamic acid

An object of the present invention is to provide a process for producing an optically active γ-hydroxy-L-glutamic acid advantageously on an industrial scale. The present invention provides a process for producing an optically active γ-hydroxy-L-glutamic acid, which comprises allowing biocatalyst I, an amino group donor, pyruvic acid and glyoxylic acid to coexist in an aqueous medium to form the optically active γ-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active γ-hydroxy-L-glutamic acid therefrom, said biocatalyst I having activity of forming the optically active γ-hydroxy-L-glutamic acid from pyruvic acid and glyoxylic acid in the presence of an amino group donor. The present invention also provides a process for producing an optically active γ-hydroxy-L-glutamic acid, which comprises allowing biocatalyst II, an amino group donor and optically active 4-hydroxy-2-ketoglutaric acid to coexist in an aqueous medium to form the optically active γ-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active 4-hydroxy-2-ketoglutaric acid therefrom, said biocatalyst II having activity of converting an optically active 4-hydroxy-2-ketoglutaric acid into the optically active γ-hydroxy-L-glutamic acid in the presence of an amino group donor.