248588-33-2

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid is used as a key intermediate in the synthesis of new pharmaceutical compounds, leveraging its unique cyclopropane ring and fluorine atom to create molecules with potential therapeutic effects.
Used in Agrochemical Research and Development:
In the agrochemical industry, 1-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid is utilized as a precursor for the development of new agrochemicals, where its chemical reactivity and structural features can contribute to the creation of effective and novel pesticides or other agricultural products.
Used in Medicinal Chemistry for Fluorine-Containing Drug Design:
1-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid is employed as a building block for the design of fluorine-containing drugs, capitalizing on the fluorine atom's ability to modulate the physicochemical and pharmacological properties of the resulting compounds, potentially improving their efficacy, selectivity, and metabolic stability.
Used in Materials Science:
1-(3-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID's unique cyclopropane ring and fluorophenyl structure also make it a candidate for applications in materials science, where it could be used in the development of new materials with specific properties, such as polymers with tailored characteristics for various industrial applications.

InChI:InChI=1/C10H9FO2/c11-8-3-1-2-7(6-8)10(4-5-10)9(12)13/h1-3,6H,4-5H2,(H,12,13)

Upstream product

• 501-00-8 3-fluorophenylacetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 124276-55-7 1-(3-fluorophenyl)cyclopropane-1-carbonitrile 

Downstream Products

• 692737-66-9 1-(3-fluorophenyl)cyclopropan-1-amine hydrochloride 
• 1446358-53-7 C₂₇H₂₁F₂N₇O₂ 
• 1268444-66-1 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(3-fluorophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 1268445-04-0 (4R)-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-1-{[1-(3-fluorophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 361211-23-6 C₁₀H₈ClFO 
• 764647-70-3 1-(3-fluorophenyl)-1-cyclopropylamine 

Relevant academic research and scientific papers

Preparation method of arylcyclopropane compound

The present invention discloses a method for preparing an arylcyclopropane compound, 1.0eq phenylacetonitrile and 1.1eq 1-bromo-2-chloroethane as the starting material, N, N- dimethylacetamide as a solvent, solvent dosage of 10V, plus 2.5eq sodium hydride

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

N-CYCLOALKYLGLYCINES AS HIV PROTEASE INHIBITORS

This invention relates generally to N-cycloalkylglycines of the Formula (I): or a stereoisomeric form, a mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, which are useful as HIV protease inhibitors, pharmaceutical compositions and diagnostic kits including the same, methods for using the same for treating viral infection or an assay standards or reagents, and intermediates and processes for making the same.