248588-33-2

Basic information

• Product Name: 1-(3-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 1-(3-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID;ASINEX-REAG BAS 10153500;TIMTEC-BB SBB010648;1-(3-Fluorophenyl)cyclopropane-1-carboxylic acid
• CAS NO: 248588-33-2
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.18
• Product Categories: Carboxylic Acids;Carboxylic Acids;Ring Systems
• Mol File: 248588-33-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 314.3°C at 760 mmHg
• Flash Point: 143.9°C
• Appearance: /
• Density: 1.361g/cm³
• Vapor Pressure: 0.000199mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(3-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID(248588-33-2)
• EPA Substance Registry System: 1-(3-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID(248588-33-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 248588-33-2(Hazardous Substances Data)

Usage

General Description

1-(3-Fluoro-phenyl)-cyclopropanecarboxylic acid is a chemical compound with a cyclopropane ring and a carboxylic acid group attached to a phenyl ring containing a fluorine atom. It is used in the research and development of pharmaceuticals and agrochemicals due to its potential as a building block for the synthesis of novel compounds. The presence of the fluorine atom on the phenyl ring also makes it useful in medicinal chemistry for the design of fluorine-containing drugs. Additionally, the cyclopropane ring confers unique chemical reactivity, which can be exploited for the creation of diverse molecular structures. Overall, this compound has potential applications in various fields, including drug discovery and materials science.

InChI:InChI=1/C10H9FO2/c11-8-3-1-2-7(6-8)10(4-5-10)9(12)13/h1-3,6H,4-5H2,(H,12,13)

Upstream product

• 501-00-8 3-fluorophenylacetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 124276-55-7 1-(3-fluorophenyl)cyclopropane-1-carbonitrile 

Downstream Products

• 692737-66-9 1-(3-fluorophenyl)cyclopropan-1-amine hydrochloride 
• 1446358-53-7 C₂₇H₂₁F₂N₇O₂ 
• 1268444-66-1 (4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-{[1-(3-fluorophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 1268445-04-0 (4R)-4-{[2-chloro-4-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}-N-(1-cyanocyclopropyl)-1-{[1-(3-fluorophenyl)cyclopropyl]carbonyl}-L-prolinamide 
• 361211-23-6 C₁₀H₈ClFO 
• 764647-70-3 1-(3-fluorophenyl)-1-cyclopropylamine 

Relevant articles and documents

Preparation method of arylcyclopropane compound

The present invention discloses a method for preparing an arylcyclopropane compound, 1.0eq phenylacetonitrile and 1.1eq 1-bromo-2-chloroethane as the starting material, N, N- dimethylacetamide as a solvent, solvent dosage of 10V, plus 2.5eq sodium hydride

N-CYCLOALKYLGLYCINES AS HIV PROTEASE INHIBITORS

This invention relates generally to N-cycloalkylglycines of the Formula (I): or a stereoisomeric form, a mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, which are useful as HIV protease inhibitors, pharmaceutical compositions and diagnostic kits including the same, methods for using the same for treating viral infection or an assay standards or reagents, and intermediates and processes for making the same.