2486-02-4

Usage

Uses

Used in Conductive Material Production:
GALLIC ACID ISOAMYL ESTER is used as a precursor in the method for producing conductive materials. It is applied for exposing a silver halide emulsion layer to gallic acid and/or its derivative, which aids in the formation of conductive materials.
Used in Pharmaceutical Industry:
GALLIC ACID ISOAMYL ESTER is used as a pharmaceutical candidate for various applications due to its antioxidant, antimicrobial, and anti-inflammatory properties. It can be employed in the development of new drugs or as an additive to enhance the efficacy of existing medications.
Used in Cosmetics Industry:
GALLIC ACID ISOAMYL ESTER can be used as an ingredient in the cosmetics industry, where its antioxidant and anti-inflammatory properties can contribute to the development of skincare products, promoting skin health and protection against environmental stressors.
Used in Food Industry:
GALLIC ACID ISOAMYL ESTER may also find applications in the food industry as a natural preservative due to its antimicrobial properties. It can help extend the shelf life of perishable products and maintain their quality.
Used in Agricultural Industry:
In the agricultural industry, GALLIC ACID ISOAMYL ESTER can be utilized as a natural pesticide or fungicide, providing protection for crops against various pests and diseases while reducing the reliance on synthetic chemicals.

InChI:InChI=1/C12H16O5/c1-7(2)3-4-17-12(16)8-5-9(13)11(15)10(14)6-8/h5-7,13-15H,3-4H2,1-2H3

Upstream product

• 123-51-3 i-Amyl alcohol 
• 149-91-7 3,4,5-trihydroxybenzoic acid 

Downstream Products

• 145643-84-1 isoamyl gallate 3-O-sulfate 
• 145643-85-2 isoamyl gallate 4-O-sulfate 

Relevant academic research and scientific papers

Design, Synthesis, and Antifungal Activity of Alkyl Gallates Against Plant Pathogenic Fungi In Vitro and In Vivo

A series of alkyl gallates was synthesized by reacting gallic acid with the corresponding alcohols. Their structures were determined on the basis of spectroscopic data, including NMR and MS. The antifungal activities of these compounds against plant pathogenic fungi in vitro and in vivo were assessed.

Synthesis and in vitro antimalarial activity of alkyl esters of gallate as a growth inhibitor of plasmodium falciparum

This study is aimed to synthesize alkyl esters gallate and determine its in vitro antimalarial activity against parasite Plasmodium falciparum. Fourteen compounds of alkyl esters gallate were synthesized by esterification of the carboxyl group of gallic acid with a series of alkyl alcohols, as well as methoxylation of the hydroxy groups on the aromatic ring of gallic acid. Antimalarial activity of the synthesized alkyl esters gallate were expressed by IC50 value, with gallic acid as an original compound and artemisin as a positive control. Compared to gallic acid, eleven synthesized compounds of alkyl esters gallate, have a greater antimalarial activity against Plasmodium falciparum. On the other hand, three compounds, that are propyl gallate, butyl gallate and trimethoxy methyl gallate, showed a lower antimalarial activity. Moreover, compared to gallic acid (IC50: 194.86 mM) and artemisin (IC50: 0.5 mM), two synthesized compounds of alkyl gallates, namely methyl gallate and hexyl gallate exhibited the stronger antimalarial activity against Plasmodium falciparum, with IC50 value of 0.03 mM and 0.11 mM, respectively. Our result clearly demonstrated that methyl gallate and hexyl gallate as a promising candidate for the new antimalarial agents.

Microwave-assisted esterification of gallic acid

An efficient synthesis of alkyl gallates under microwave irradiation was described. The reaction took place in 6-10 mins, which was much shorter than the traditional synthetic methods, with almost quantitative yields.

Antifungal activity of alkyl gallates against plant pathogenic fungi

The antifungal activity of alkyl gallates against plant pathogenic fungi was evaluated. All of the fungi tested in this study were susceptible to some alkyl gallates, and the effect of linear alkyl gallates against plant pathogenic fungi was similar to the previously reported effects against Gram-negative and Gram-positive bacteria. We found that branched alkyl gallates showed stronger activity than did linear alkyl gallates with similar log P values. In addition, the antifungal activity of alkyl gallates was correlated with gallate-induced inhibition of the activity of mitochondrial complex II. The antifungal activity of alkyl gallates likely originates, at least in part, from their ability to inhibit the membrane respiratory chain.