248602-65-5

Basic information

• Product Name: (E)-3-Dimethoxyphsphoryl-4-(4-methoxyphenyl)but-3-en-2-one
• Synonyms: (E)-3-Dimethoxyphsphoryl-4-(4-methoxyphenyl)but-3-en-2-one
• CAS NO: 248602-65-5
• Molecular Weight: 284.249
• Mol File: 248602-65-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-Dimethoxyphsphoryl-4-(4-methoxyphenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-Dimethoxyphsphoryl-4-(4-methoxyphenyl)but-3-en-2-one(248602-65-5)
• EPA Substance Registry System: (E)-3-Dimethoxyphsphoryl-4-(4-methoxyphenyl)but-3-en-2-one(248602-65-5)

Safety Data

• Hazardous Substances Data: 248602-65-5(Hazardous Substances Data)

Upstream product

• 4202-14-6 dimethyl (2-oxopropyl)phosphonate 
• 40891-01-8 4-(dimorpholinomethyl)-1-methoxybenzene 

Relevant articles and documents

Hetero-Diels-Alder reactions of α-carbonylated styrylphosphonates with enol ethers. High-pressure influence on reactivity and diastereoselectivity

Variously substituted α-carbonylated styrylphosphonates 5 were easily prepared by Knoevenagel-type syntheses, and used as oxadienes in hetero-Diels-Alder [4 + 2] cycloadditions with enol ethers, to give new phosphonylated 3,4-dihydro-2H-pyrans 6. It was confirmed that the reactivity, as well as the trans-diastereoselectivity of the reaction, was significantly enhanced by the use of high-pressure conditions, particularly in the presence of ButOH as a co-solvent. Moreover, a one-pot synthesis of 6 via a tandem-sequence Knoevenagel and hetero-Diels-Alder reactions was achieved.