40891-01-8

Upstream product

• 110-91-8 morpholine 
• 123-11-5 4-methoxy-benzaldehyde 
• 122668-91-1 N-<α-(benzotriazol-1-yl)-α-(4-methoxyphenyl)methyl>morpholine 
• 21185-25-1 p-methoxybenzal chloride 

Downstream Products

• 123-11-5 4-methoxy-benzaldehyde 
• 248602-65-5 (E)-3-Dimethoxyphsphoryl-4-(4-methoxyphenyl)but-3-en-2-one 
• 1257405-23-4 C₁₉H₂₁ClN₂O₃ 
• 1257405-21-2 C₁₉H₂₁N₃O₅ 
• 1257405-25-6 C₂₀H₂₄N₂O₃ 
• 1257405-22-3 C₁₉H₂₁ClN₂O₃ 
• 1409957-43-2 4-(2,2-difluoro-1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethyl)morpholine 

Relevant academic research and scientific papers

Enhanced corrosion inhibitive effect of p-methoxybenzylidene-4,4′-dimorpholine assembled on nickel oxide nanoparticles for mild steel in acid medium

The corrosion inhibition efficiency of p-methoxybenzylidene-4,4′-dimorpholine (p-MBDM) and p-MBDM assembled on nickel oxide nanoparticles (NiONPs) was investigated using three techniques: weight loss, electrochemical impedance spectroscopy (EIS), and galv

Rediscovering aminal chemistry: Copper(ii) catalysed formation under mild conditions

Aminals, the N,N analogues of acetals, have been thoroughly explored in organic chemistry, with a particular focus on heteroaromatic aldehyde lithiation. Nevertheless, the existing methodologies for their formation typically employ harsh conditions limiting their usefulness. In this work, we present an efficient and mild methodology for the preparation of aminals from aromatic aldehydes, including furanic platforms. These mild conditions allowed ease of access to a plethora of aminals and as such we set out to explore previously unaccessible potential applications. By studying the stability of various aminals, we were able to develop a simple aldehyde protecting group based on a commercial diamine which is deprotected under mind conditions. We developed a protocol for the scavenging of genotoxic aldehydes by taking advantage of our methodology and a diamine resin, as well as early studies on the development of a stimuli-responsive release system using a salycil aldehyde derived aminal. This journal is

Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum.

CHEMICAL PROCESSES AND COMPOUNDS DERIVED THEREFROM

The present invention relates to N-substituted anilines and derivatives thereof and in particular to chemical processes for the preparation of N-substituted anilines and derivatives thereof.

A new protocol for the preparation of aminals from aromatic aldehydes and their facile conversion to phosphonates

A new and fast method for the preparation of aminals is reported from the reaction of aromatic aldehydes and secondary amines in the presence of potassium carbonate in high yields. The aminal can be converted to the corresponding iminum salt in reaction with acetyl chloride very easily and in very short time with high yield. Addition of trialkylphosphite, as one possible nucleophile, to the prepared iminium salt produces the α-amino phosphonate in very high yield.

Aminal Exchange

Reactions of N-(α-benzotriazolylalkyl)-N,N-dialkylamines with the dialkylamine corresponding to the dialkylamino substituent afford symmetrical aminals in good yields.Treatment with other dialkylamines gives mixtures of the unsymmetrical and the two symme

Novel synthesis of α-acetylstyrylphosphonates

α-Acetylstyrylphosphonates were conveniently synthesized from 2-oxopropylphosphonates and substituted (dimorpholinomethyl)-benzenes (animals). 4-Benzylidenemorpholinium carboxylates, generated from animals by the action of α-halo acids, reacted with the phosphonates to give the products by elimination of the amine. The yields were influenced by the nature of substituents and their position in the phenyl ring and could be improved by adjustment of the acidities of the reacted acids. α-Acetylstyrylphosphonates containing various substituents on every position (at the 2-, 3-, or 4-position) in the phenyl ring were obtained generally in excellent yields using monochloroacetic acid.

AMINOMETHYLATION OF 2,6-DI-TERT-BUTYLPHENOL BY THE AMINALS OF AROMATIC ALDEHYDES

The reaction of 2,6-di-tert-butylphenol with the aminals of aromatic aldehydes gave its 4-aryldialkylaminomethyl derivatives.