24863-39-6Relevant academic research and scientific papers
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase
Ding, Yili,Girardet, Jean-Luc,Smith, Kenneth L.,Larson, Gary,Prigaro, Brett,Lai, Vicky C.H.,Zhong, Weidong,Wu, Jim Z.
, p. 675 - 678 (2007/10/03)
From compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, we identified a pteridine hit compound with an IC50 of 15 μM. Our SAR studies were focused on the different groups at the 6- and 7-positions, substitutions at the 4-position, and replacement of N1 or N3 with carbon in the pteridine ring. We found that NH or OH at 4-position is critical for the inhibitory activity. Furthermore, a hydrophobic substituent at the 4-position may help compounds permeate through the cell membrane.
On the Amination of Pteridines by Liquid Ammonia-Potassium Permanganate
Sladowska, H.,De Meester, J. W. G.,Plas, H. C. van der
, p. 477 - 480 (2007/10/02)
7-Phenyl, 7-(p-methoxyphenyl)-, 7-methyl-, 7-t-butyl-, 6,7-diphenyl-, 6,7-dimethyl- and 2-phenylpteridine are converted in good yields into their respective 4-amino compounds, when they are dissolved in liquid ammonia (-40 deg) and potassium permanganate
Alkylamination of Pteridines by Primary Alkylamines - Potassium Permanganate
Sladowska, H.,van Veldhuizen, A.,van der Plas, H. C.
, p. 843 - 847 (2007/10/02)
Reaction of 7-phenyl, 7-p-methoxyphenyl, 7-t-butyl- and 6,7-diphenylpteridine with ethylamine and t-butylamine in the presence of potassium permanganate leads to the introduction of the ethylamino or t-butylamino group at C-4 in the above-mentioned pterid
