24867-24-1Relevant articles and documents
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors
Cheung, Adrian Wai-Hing,Banner, Bruce,Bose, Jolly,Kim, Kyungjin,Li, Shiming,Marcopulos, Nicholas,Orzechowski, Lucja,Sergi, Joseph A.,Thakkar, Kshitij C.,Wang, Bing-Bing,Yun, Weiya,Zwingelstein, Catherine,Berthel, Steven,Olivier, Andree R.
, p. 7518 - 7522 (2013/02/21)
High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors. Structural modification of diaminopyrroloquinazoline series resulted in pyrido[2,3-d]pyrimidine-2,4-diamine series which was further optimized to give compounds 5 and 24 as potent, selective (except T-cell phosphatase) PTP1B inhibitors with good mouse PK properties.
