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Vitamin Ks-II, also known as menaquinones, are a group of fat-soluble vitamins that play a crucial role in blood clotting and bone metabolism. They are synthesized by bacteria in the gut and are found in various foods, such as green vegetables, meat, and dairy products. Vitamin Ks-II are essential for the activation of proteins involved in blood coagulation, ensuring proper blood clotting and preventing excessive bleeding. Additionally, they contribute to bone health by regulating the balance between bone formation and resorption, thus maintaining bone density and strength. A deficiency in Vitamin Ks-II can lead to increased risk of bleeding and weakened bones, while an excess can cause issues with blood clotting.

2487-39-0

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2487-39-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2487-39-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2487-39:
(6*2)+(5*4)+(4*8)+(3*7)+(2*3)+(1*9)=100
100 % 10 = 0
So 2487-39-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H12O4S/c1-8-12(17)9-4-2-3-5-10(9)13(18)14(8)19-7-6-11(15)16/h2-5H,6-7H2,1H3,(H,15,16)

2487-39-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(3-methyl-1,4-dioxonaphthalen-2-yl)sulfanylpropanoic acid

1.2 Other means of identification

Product number -
Other names 3-(3-Methyl-1,4-dioxo-1,4-dihydro-[2]naphthylmercapto)-propionsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2487-39-0 SDS

2487-39-0Relevant academic research and scientific papers

Synthesis and anticancer evaluation of vitamin K3 analogues

Chen, Chinpiao,Liu, Yi-Zhong,Shia, Kak-Shan,Tseng, Huan-Yi

, p. 2729 - 2732 (2002)

Novel vitamin K3 analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (±)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, S

The role of a quinone methide in the sequence specific alkylation of DNA

Chatterjee, Moneesh,Rokita, Steven E.

, p. 1690 - 1697 (1994)

Oligonucleotide-naphthoquinone conjugates were prepared and examined for use as inducible, site-directed alkylating agents of DNA. Reaction was found to be sequence specific and under control of either biomimetic reduction or near-UV irradiation. Both conditions induced the formation of a transient and highly electrophilic intermediate consistent with a quinone methide. Enzymatic reduction of 5-((mesyloxy)methyl)- and 5-(bromomethyl)naphthoquinone derivatives produced cross-linking between a target and probe sequence, but the equivalent 5-(acetoxymethyl), 5-(hydroxymethyl) and 5-methyl analogues were predictably inactive. Conversely, irradiation of the 5-methylnaphthoquinone derivative produced cross-linking through a mechanism of photochemical enolization that was not available to the 6-methyl, 3-methyl, or unsubstituted analogues. Hydroxyl radical footprinting of the modified DNA demonstrated that guanine and cytosine were targets of alkylation.

THERAPEUTIC COMPOUNDS AND METHODS

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Page/Page column 0177, (2018/11/22)

The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)

Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents

Mecklenburg, Susanne,Shaaban, Saad,Ba, Lalla A.,Burkholz, Torsten,Schneider, Thomas,Diesel, Britta,Kiemer, Alexandra K.,Roeseler, Anne,Becker, Katja,Reichrath, Joerg,Stark, Alexandra,Tilgen, Wolfgang,Abbas, Muhammad,Wessjohann, Ludger A.,Sasse, Florenz,Jacob, Claus

scheme or table, p. 4753 - 4762 (2009/12/08)

Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the

Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties

Braud, Emmanuelle,Goddard, Mary-Lorene,Kolb, Stephanie,Brun, Marie-Priscille,Mondesert, Odile,Quaranta, Muriel,Gresh, Nohad,Ducommun, Bernard,Garbay, Christiane

scheme or table, p. 9040 - 9049 (2009/04/11)

CDC25 phosphatases are considered as attractive targets for anti-cancer therapy. To date, quinone derivatives are among the most potent inhibitors of CDC25 phosphatase activity. We present in this paper the synthesis and the biological evaluation of new q

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