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Usage

Uses

Used in Pharmaceutical Industry:
[(4-chlorophenyl)amino]acetonitrile is used as a building block in organic synthesis for the preparation of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, [(4-chlorophenyl)amino]acetonitrile serves as a crucial intermediate in the synthesis of various agrochemicals, contributing to the creation of effective products for pest control and crop protection.
Used in Dye Manufacturing:
[(4-chlorophenyl)amino]acetonitrile is also utilized in the manufacturing of dyes, where its chemical properties are leveraged to produce a range of colorants for different applications.
Used in the Production of Fine Chemicals:
Furthermore, [(4-chlorophenyl)amino]acetonitrile finds application in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavorings, for their high specificity and reactivity.

InChI:InChI=1/C8H7ClN2/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4,11H,6H2

Upstream product

• 50-00-0 formaldehyd 
• 106-47-8 4-chloro-aniline 
• 151-50-8 potassium cyanide 
• 372-09-8 cyanoacetic acid 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 67083-84-5 2-(4-chlorophenylaminomethyl)imidazoline 
• 705930-77-4 3-(4-chlorophenyl)-4-(4-chloropyrazol-1-yl)-4,5-dihydro-1-pyrazolcarboxylic acid (N-cyanomethyl)-4-chloroanilide 
• 1204614-45-8 (p-chlorophenyl)iminoacetonitrile 
• 62166-66-9 2-(p-chlorophenyl)iminomalononitrile 
• 54735-06-7 8-chloro-1,10-diphenyl-3,4-dihydro-pyrazino[1,2-a]indole 
• 78367-16-5 8-Chloro-1-methyl-10-phenyl-3,4-dihydro-pyrazino[1,2-a]indole 
• 78367-06-3 N-[2-(5-Chloro-3-phenyl-indol-1-yl)-ethyl]-acetamide 
• 78367-30-3 (5-Chloro-3-phenyl-indol-1-yl)-acetic acid 
• 54735-01-2 1-(2-Benzoylaminoaethyl)-5-chlor-3-phenylindol 
• 39537-63-8 2-(5-chloro-3-phenyl-indol-1-yl)-ethylamine 
• 54734-92-8 (5-chloro-3-phenyl-indol-1-yl)-acetonitrile 
• 672333-13-0 N-(cyanomethyl)-N-(4-chlorophenyl)formamide 
• 14088-84-7 N-(4-chlorophenyl)ethylenediamine 
• 21979-12-4 N-(4-chloro-phenyl)-glycine amide 

Relevant academic research and scientific papers

Heterocycle Syntheses with Anionic N-Heterocyclic Carbenes: Ring Transformations of Sydnone Imine Anions

Sydnone imines were deprotonated at the C4 position to give lithium-stabilized anions, which proved to be stable for several months in solution. These anions are elements of the intersection of the substance classes of N-heterocyclic carbenes and mesomeric betaines. They can be formulated as anionic N-heterocyclic carbenes. The negative charge translates into high-field shifts of the 13C NMR resonance frequencies of C4 in comparison to other NHCs. Similar to the chemistry of N-heterocyclic carbenes, reactions with isocyanates and isothiocyanates gave 4-(N-carbamoyl)-benzoylsydnone imines in trapping reactions. As a result of ring transformations involving the characteristic π-architecture of the mesoionic framework, imidazolidine-2,4-dithiones, imidazolin-2,4-diones and 1,2,4-triazol-5-ones were formed depending on the substitution pattern of the starting materials and the reaction conditions.

Preparation method for alpha-cyanoamine

The invention discloses a preparation method for alpha-cyanoamine. According to the method, the product alpha-cyanoamine is prepared through nucleophilic substitution in a mixed solvent in the presence of an oxidizing agent with an amine compound and cyanoacetic acid as reactants, iodide as a catalyst and sodium acetate as alkali. The catalyst used in the method has high reactivity; reaction conditions are mild; the application scope of a substrate is wide; post-treatment is convenient; the yield of the target product is high; preparation process is simple, green and environment-friendly; and used raw materials are widely available.

Cyanoacetic Acid as a Masked Electrophile: Transition-Metal-Free Cyanomethylation of Amines and Carboxylic Acids

Using cyanoacetic acid as a masked electrophile, a new cyanomethylation reaction of amines and carboxylic acids was developed, producing a variety of α-aminonitriles and cyanomethyl esters with good yields and excellent functionality tolerance. This protocol features simple manipulation, inexpensive reagents, and a wide substrate scope. Iodoacetonitrile was generated in situ from the iodination-decarboxylation of cyanoacetic acid in this transformation.

Design, synthesis and glutathione peroxidase-like properties of ovothiol-derived diselenides

Eleven imidazole diselenides derived from the naturally occurring family of antioxidants, the ovothiols, were synthetised by cyclisation of selenoamides with trimethylsilyltrifluoromethanesulfonate or refluxing of cyanoamines in a selenium/sodium borohydride mixture. These compounds were assayed for their glutathione peroxidase-like (GSH Px-like) activity and their capacity to be reduced by glutathione. The most active molecules of the series were 4 times more potent in the GSH Px-like test than the widely known reference compound, ebselen. This catalytic activity was mediated by the formation of the antioxidant selenol intermediate upon partial but significant exchange reaction with glutathione.