2489-52-3 Usage
General Description
3-fluorosulphonylbenzenesulphonyl chloride is a chemical compound with the molecular formula C6H4ClFO4S2. It is an organofluorine compound that is commonly used as a building block in organic synthesis. 3-fluorosulphonylbenzenesulphonyl chloride is a sulfonyl chloride, which means it contains a functional group with a sulfur atom bonded to two oxygen atoms and a chlorine atom. 3-fluorosulphonylbenzenesulphonyl chloride is an important intermediate in the production of pharmaceuticals, agrochemicals, and other chemical products. It is known for its high reactivity and is used in the synthesis of various organic compounds through nucleophilic substitution reactions. 3-fluorosulphonylbenzenesulphonyl chloride is handled and used with caution due to its potential reactivity and toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 2489-52-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2489-52:
(6*2)+(5*4)+(4*8)+(3*9)+(2*5)+(1*2)=103
103 % 10 = 3
So 2489-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClFO4S2/c7-13(9,10)5-2-1-3-6(4-5)14(8,11)12/h1-4H
2489-52-3Relevant articles and documents
(Chlorosulfonyl)benzenesulfonyl Fluorides - Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
Tolmachova, Kateryna A.,Moroz, Yurii S.,Konovets, Angelika,Platonov, Maxim O.,Vasylchenko, Oleksandr V.,Borysko, Petro,Zozulya, Sergey,Gryniukova, Anastasia,Bogolubsky, Andrey V.,Pipko, Sergey,Mykhailiuk, Pavel K.,Brovarets, Volodymyr S.,Grygorenko, Oleksandr O.
, p. 672 - 680 (2018/11/23)
Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor.
