2489-52-3 Usage
Uses
Used in Pharmaceutical Industry:
3-fluorosulphonylbenzenesulphonyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals. Its reactivity allows for the creation of a wide range of organic compounds through nucleophilic substitution reactions, which are vital in developing new drugs and improving existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 3-fluorosulphonylbenzenesulphonyl chloride is utilized as a building block in the development of pesticides and other agricultural chemicals. Its role in organic synthesis contributes to the production of effective and targeted agrochemicals that aim to enhance crop protection and yield.
Used in Organic Synthesis:
3-fluorosulphonylbenzenesulphonyl chloride is employed as a reactive building block in organic synthesis across various chemical industries. Its ability to participate in nucleophilic substitution reactions makes it a valuable component in creating diverse organic compounds for different applications, including specialty chemicals and materials.
It is important to handle 3-fluorosulphonylbenzenesulphonyl chloride with care due to its potential reactivity and toxicity, ensuring safety measures are in place throughout its use in research and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 2489-52-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2489-52:
(6*2)+(5*4)+(4*8)+(3*9)+(2*5)+(1*2)=103
103 % 10 = 3
So 2489-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClFO4S2/c7-13(9,10)5-2-1-3-6(4-5)14(8,11)12/h1-4H
2489-52-3Relevant academic research and scientific papers
(Chlorosulfonyl)benzenesulfonyl Fluorides - Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
Tolmachova, Kateryna A.,Moroz, Yurii S.,Konovets, Angelika,Platonov, Maxim O.,Vasylchenko, Oleksandr V.,Borysko, Petro,Zozulya, Sergey,Gryniukova, Anastasia,Bogolubsky, Andrey V.,Pipko, Sergey,Mykhailiuk, Pavel K.,Brovarets, Volodymyr S.,Grygorenko, Oleksandr O.
, p. 672 - 680 (2018/11/23)
Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor.
