248927-82-4Relevant articles and documents
A novel silyl linker: Motif for side chain tethered approach to solid- phase glycopeptide synthesis
Nakamura, Kazuhiko,Ishii, Akira,Ito, Yukishige,Nakahara, Yoshiaki
, p. 11253 - 11266 (2007/10/03)
In order to facilitate the solid-phase syntheses of protected glycopeptide blocks, we designed a novel silyl linker, which allows the alcoholic side chain (carbohydrate, serine, or threonine) of (glyco-)peptides to link to the solid support. Utilizing this linker, peptide coupling reactions at both the N- and the C-termini were successful. Synthesis of the glycophorin AM fragment corresponding to the N-terminal glycoheptapeptide is demonstrated.